Abstract：Folic acid is one of the essential nutrients for human health. Folic acid supplementation during pregnancy is important to prevent fetal neural tube defects. This article briefly reviews its current clinical use from the basic characteristics and mechanism of folic acid, and also reviews the latest literature of fetal, neonatal and children. The terms such as “fetus”, “newborn”, “folate”, “infant, newborn” [Mesh], and “folic acid” [Mesh] are used to search for relevant research from China National Knowledge Infrastructure, Wanfang, PubMed and The Cochrane Library. Summary of domestic and foreign studies: folic acid may be associated with fetal neural tube defects, the relationship between folic acid and fetal birth defects, fetal growth restriction and perinatal mortality remains to be further studied; in addition, folic acid is associated with neonatal asphyxia and brain injury; may be associated with childhood asthma, mental retardation and immunity. It can be seen that although the correlation between folic acid and various diseases still needs more scientific research, it is recommended that periconception and pregnant should reasonably supplement folic acid.
王安妮, 丁新, 冯欣. 孕期叶酸水平对子代生长发育影响的研究进展[J]. 中国药学杂志, 2020, 55(14): 1138-1142.
WANG An-ni, DING Xin, FENG Xin. The Effects of Folic Acid in Fetuses and Newborns. Chinese Pharmaceutical Journal, 2020, 55(14): 1138-1142.
WILSON R D, DAVIES G, DÉSILETS V, et al. The use of folic acid for the prevention of neural tube defects and other congenital anomalies[J]. J Obstet Gynancol Can, 2003, 25(11):959-973.
HOFFBRAND A V, WEIR D G. The history of folic acid[J]. Br J Haematol, 2001, 113(3):579-589.
NADERI N, HOUSE J D. Recent developments in folate nutrition[J]. Adv Food Nutr Res, 2018, 83:195-213.
HALSTED C H. The intestinal absorption of folates[J]. Am J Clin Nutr, 1979, 32(4):846-855.
PIETRZIK K, BAILEY L, SHANE B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics[J]. Clin Pharmacokinet, 2010, 49(8):535-548.
HAY G, CLAUSEN T, WHITELAW A, et al. Maternal folate and cobalamin status predicts vitamin status in newborns and 6-month-old infants[J]. J Nutr, 2010, 140(3):557-564.
RONDO P H C, TOMKINS A M. Folate and intrauterine growth retardation[J]. Ann Trop Paediatr, 2000, 20(4):253-258.
HUTSON J R, STADE B, LEHOTAY D C, et al. Folic acid transport to the human fetus is decreased in pregnancies with chronic alcohol exposure[J]. PLoS One, 2012, 7(5):e38057.
XIE X. Obstetrics and Gynecology(妇产科学)(9th Ed) [M]. Beijing: People′s Medical Publishing House, 2018.
LEUNG K Y, PAI Y J, CHEN Q, et al. Cartitioning of one-carbon units in folate and methionine metabolism is essential for neural tube closure[J]. Cell Rep, 2017, 21(7):1795-1808.
CZEIZEL A E, DUDAS I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation[J]. N Engl J Med, 1992, 327(26):1832-1835.
Group on Guidelines for the Prevention of Neural Tube Defects by Supplementing Folic Acid. Guideline for the Prevention of Neural Tube Defects by Periconceptional Folic Acid Supplementation (2017) [J]. Chin J Reprod Heal(中国生育健康杂志), 2017,28(5):401-410.
BIBBINS-DOMINGO K, GROSSMAN D C, CURRY S J, et al. Folic acid supplementation for the prevention of neural tube defects: US preventive services task force recommendation statement[J]. JAMA, 2017, 317(2):183-189.
VISWANATHAN M, TREIMAN K A, KISH-DOTO J, et al. Folic acid supplementation for the prevention of neural tube defects: an updated evidence report and systematic review for the US preventive services task force[J]. JAMA, 2017,317(2):190-203.
DE-REGIL L M, PENA-ROSAS J P, FERNANDEZ-GAXIOLA A C, et al. Effects and safety of periconceptional oral folate supplementation for preventing birth defects[J]. Cochrane Database Syst Rev, 2015,(12):Cd007950.
LIU Y L, CHEN X H, ZHANG F M, et al. Relationship between nutritional status of pregnant women and birth defects[J]. J Shanxi Coll Tradit Chin Med(山西中医学院学报), 2015,(5):56-58.
FARIA D J, SIMOES M J, TEIXEIRA L C, et al. Effect of folic acid in a modified experimental model of anorectal malformations adriamycin-induced in rats[J]. Acta Cir Bras, 2016, 31(1):22-27.
MUNGER R G, TAMURA T, JOHNSTON K E, et al. Oral clefts and maternal biomarkers of folate-dependent one-carbon metabolism in utah[J]. Birth Defects Res A Clin Mol Teratol, 2011, 91(3):153-161.
GILDESTAD T, BJORGE T, VOLLSET S E, et al. Folic acid supplements and risk for oral clefts in the newborn: a population-based study[J]. Br J Nutr, 2015, 114(9):1456-1463.
XU W, HAN W T. Research progress on the relationship between MTHFR gene and nonsyndromic cleft lip and palate[J]. Chin Mod Med(中国当代医药), 2016,23(11):20-22.
FIGUEIREDO J C, LY S, RAIMONDI H, et al. Genetic risk factors for orofacial clefts in Central Africans and Southeast Asians[J]. Am J Med Genet A, 2014, 164a(10):2572-2580.
ZHAI J H, SONG A Q,GUO L Y, et al. Research on relationship between neonatal weight and dietary,medicine factors during pregnancy[J]. Chin J Child Health Care(中国儿童保健杂志), 2013,21(11):1215-1218.
GUO H Q. The effect of folic acid intake on pretermbirth, low birth weight and small gestational ageduring the perinatal period [D]. Gansu:Lanzhou University, 2018.
FANG Y, LU Y Q, XUE Y, et al. Evaluation of the effect of folic acid intervention in people at risk of folic acid metabolism disorder [J]. Chin J Matern Child Health Care(中国妇幼保健), 2016,31(22):4805-4806.
WANG K M. Correlation between fetal growth restriction and maternal erythrocyte folate deficiency [J].Jilin Med J(吉林医学), 2015:271-271.
XIONG H. Correlation analysis of fetal growth restriction and maternal erythrocyte folate deficiency [J]. Contemp Med(当代医学), 2015,21(24):86-87.
MALHOTRA N, UPADHYAY R P, BHILWAR M, et al. The role of maternal diet and iron-folic acid supplements in influencing birth weight: evidence from India′s National Family Health Survey[J]. J Trop Pediatr, 2014, 60(6):454-460.
GRIEGER J A, CLIFTON V L. A review of the impact of dietary intakes in human pregnancy on infant birthweight[J]. Nutrients, 2014, 7(1):153-178.
CHEN Y, LEI Y L, LAN W W, et al. The effect of maternal serum folate and homocysteine levels on fetal outcomes [J]. Chinese J Health Lab Technol(中国卫生检验杂志), 2019,29(11):1363-1365.
HAN H M, SHEN H, WANG Y B, et al. Polymorphism 677 of methylenetetrahydrofolate reductase gene, hyperhomocysteinemia and recurrent miscarriage[J]. Reprod Contracept(生殖与避孕), 2012,32(7):486-489,477.
ZHAO M L. Clinical significance of detection of serum folic acid and homocysteine levels in early pregnancy and analysis of clinical efficacy in preventing pregnancy complications and fetal birth defects [J]. Chin J Matern Child Health Care(中国妇幼保健), 2019,34(6):1249-1251.
MI W Y, LIU W, LIU T C, et al. Serum levels of homocysteine and folate in neonates with asphyxia [J]. Chin J Contemp Pediatr(中国当代儿科杂志), 2008,10(2):130-132.
REVAKOVA T, VASILENKOVA A, UJHAZY E, et al. Impact of asphyxia on red blood cell folate concentration levels in newborns[J]. Bratisl Lek Listy, 2015, 116(7):417-421.
FOURNIER P, FOURCADE J, RONCALLI J, et al. Homocysteine in chronic heart failure[J]. Clin Lab, 2015, 61(9):1137-1145.
HUANG J H, WANG L L, JIANG H W, et al. The relationship between folic acid level in late pregnancy and neonatal birth rate of hypoxic-ischemic encephalopathy [J]. Chin Med Herald(中国医药导报), 2010,7(17):166-167.
WANG J, HUANG J H, LIU H L, et al. Correlation between neonatal hypoxic-ischemic encephalopathy and folic acid [J]. Chin Mod Med(中国当代医药), 2010,17(18):173-173.
BAZZANO L A, REYNOLDS K, HOLDER K N, et al. Effect of folic acid supplementation on risk of cardiovascular diseases: a Meta-analysis of randomized controlled trials[J]. JAMA, 2006, 296(22):2720-2726.
YONG S B, WU C C, WANG L, et al. Influence and mechanisms of maternal and infant diets on the development of childhood asthma[J]. Pediatr Neonatol, 2013, 54(1):5-11.
HOLLINGSWORTH J W, MARUOKA S, BOON K, et al. In utero supplementation with methyl donors enhances allergic airway disease in mice [J]. J Clin Invest, 2016, 126(5):2012.
HABERG S E, LONDON S J, STIGUM H, et al. Folic acid supplements in pregnancy and early childhood respiratory health [J]. Arch Dis Child, 2009, 94(3):180-184.
HABERG S E, LONDON S J, NAFSTAD P, et al. Maternal folate levels in pregnancy and asthma in children at age 3 years[J]. J Allergy Clin Immunol, 2011, 127(1):262-264, 264.e261.
VAN BEYNUM I M, SMEITINK J A, DEN HEIJER M, et al. Hyperhomocysteinemia: a risk factor for ischemic stroke in children[J]. Circulation, 1999, 99(16):2070-2072.
SU Y Y. Effect of environmental risk factor on children with autism disorder and mental retardation [D].Tianjin: Tianjin Medical University, 2012.
ENTRINGER S, EPEL E S, LIN J, et al. Maternal folate concentration in early pregnancy and newborn telomere length[J]. Ann Nutr Metab, 2015, 66(4):202-208.
ZHAO X, PANG X, WANG F, et al. Maternal folic acid supplementation and antibody persistence 5 years after hepatitis B vaccination among infants[J]. Hum Vaccin Immunother, 2018, 14(10):2478-2484.
MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the medical research council vitamin study. MRC vitamin study research group [J]. Lancet, 1991, 338(8766):131-137.