Abstract：OBJECTIVE To analyze the potential adulterations in a traditional Chinese medicine hospital preparation for the treatment of rheumatism. METHODS The suspicious crystalline substances were isolated under a stereoscopic microscope, and analyzed with GC-MS and UHPLC-MS. GC-MS measurements were preformed on an Agilent HP-5MS column with ion electron impact ionization. UHPLC-MS measurements were preformed with Agilent Zorbax SB-C18 as stationary phase and the mixture of acetontrile-0.1% formic acid as mobile phase under electronic spray ionization mode. RESULTS Five kinds of chemical drugs were identified from the hospital preparation, including piroxicam, prednisone acetate, indomethacin, ibuprofen and vitamin B2. CONCLUSION More attention should be paid to the adulteration in some hospital preparations.
何轶, 李静, 余坤子, 王菲菲, 张聿梅, 于健东, 戴忠, 马双成. 某抗风湿中药医院制剂中添加结晶样物质的检测[J]. 中国药学杂志, 2020, 55(7): 549-556.
HE Yi, LI Jing, YU Kun-zi, WANG Fei-fei, ZHANG Yu-mei, YU Jian-dong, DAI Zhong, MA Shuang-cheng. Analysis of Crystalline Substances in a TCM Hospital Preparation for Treatment of Rheumatism. Chinese Pharmaceutical Journal, 2020, 55(7): 549-556.
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2020, Vol. 55 
