Chemical Constituents from Stellera chamaejasme Linn.
ZHANG Nuan1a,2a, HE Jun2b, DING Kang1b, ZHANG Ya-yao1b, MA Bing-zhi2b, LI Dong2b, ZHANG Wei-ku2a*, XU Jie-kun1a*
1a. School of Life Sciences, 1b. School of Chinese Materia Medica , Beijing University of Chinese Medicine, Beijing 100029, China; 2a.Institute of Clinical Medical Sciences, 2b. Department of Pharmacy , China-Japan Friendship Hospital, Beijing 100029, China
Abstract：OBJECTIVE To study the chemical constituents from the roots of Stellera chamaejasme Linn. METHODS The 95% ethanol extract of the roots of Stellera chamaejasme Linn. was fractionalized by using petroleum ether, dichloromethane and ethyl acetate, respectively. The extraction parts were isolated by various chromatographic methods including silica gel, ODS column and preparative HPLC methods. Their structures were elucidated on the basis of spectroscopic data such as HR-ESI-MS and NMR. RESULTS Seventeen compounds were isolated and identified as follows: naringenin (1), (-)-epiafzelechin (2), (+)-epiafzelechin (3), 2,6,2',6'-tetramethoxy-4,4'-bis (2,3-epoxy-1-hydroxypropyl) biphenyl (4), 8-hydroxypluviatolide (5), (-)-syringaresinol (6), prestegane B (7), 7-hydroxycoumarin (8), daphnoretin (9), 3-(2,4-dihydroxyphenyl) propanoic acid methyl ester (10), 3,4-dihydroxystyryl alcohol (11), 3-[(1E)-3-hydroxy-1-propen-1-yl]-2, 5-dimethoxyphenyl-β-D-glucopyranoside(12), Z-octadecyl caffeate (13), 1-glyceryl linolenate (14), glycerol monolinoleate (15), 2, 3-dihydroxypropyl-9-octadecenoate (16) and β-sitosterol (17). CONCLUSION Compounds 1, 2, 4, 5, 9-15 are reported from the genus Stellera Linn. for the first time.
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2020, Vol. 55 
