Analysis of Distribution of Chemotherapy Drug-Related Single Nucleotide Polymorphisms in Cancer Patients
MA Xu, LIU Ying, LI Ran, ZHANG Guan-min, BAI Yu, SHI Rui, ZHAO Bing-qing, ZHANG Yan-hua*
Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Pharmacy, Peking University Cancer Hospital & Institute, Beijing 100142, China
Abstract：OBJECTIVE To explore the distribution characteristics of chemotherapy drug-related single nucleotide polymorphisms(SNPs) in cancer patients in our hospital, and to provide the clinical reference for clinical pharmacists to guide the individualized therapy of cancer patients based on SNPs. METHODS Fluorescence-labelled specific probes were used to detect drug-related genes by fluorescence in situ hybridization. The drug-related SNPs of cancer patients from Apr 2016 to Dec 2018 in Peking University Cancer Hospital were retrospectively analyzed. SPSS24.0 software was used to statistically analyze the difference in the frequency distribution of alleles and genotypes, and the Hardy-Weinberg equilibrium test. The distribution characteristics of related gene loci in cancer patients in our hospital regarding the genotype frequency of different populations were studied. RESULTS A total of 17 chemotherapy drug-related gene loci were detected in 2 554 patients. CYP2D6(100C>T) and ABCB1(2677T>G) were not consistent with Hardy-Weinberg equilibrium, while the remaining 15 loci were in Hardy-Weinberg equilibrium. The allele frequencies of DPD, CYP2D6 and UGT1A1 of the Chinese population are significantly different from those of foreign population, which are consistent with internal reports. CONCLUSION The distribution of chemotherapy drug-related SNPs in Chinese tumor patients performs its characteristics. Clinical pharmacists should provide individualized medication advisements according to chemotherapy drug-related SNPs. Based on the application of pharmacogenomics, while referring to international databases such as PharmGKB, the interpretation of SNPs of the Chinese population should be combined with the characteristics of the Chinese population, and the database of the different population cannot be fully referenced.
马旭, 刘颖, 李然, 张关敏, 白羽, 史蕤, 赵冰清, 张艳华. 肿瘤患者化疗药物相关单核苷酸多态性分布分析[J]. 中国药学杂志, 2020, 55(8): 656-662.
MA Xu, LIU Ying, LI Ran, ZHANG Guan-min, BAI Yu, SHI Rui, ZHAO Bing-qing, ZHANG Yan-hua. Analysis of Distribution of Chemotherapy Drug-Related Single Nucleotide Polymorphisms in Cancer Patients. Chinese Pharmaceutical Journal, 2020, 55(8): 656-662.
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2020, Vol. 55 
