Abstract：OBJECTIVE To establish the HPLC fingerprint of Jinyinhua formula granules (JYHFG), and compare the qualities of the products from nine enterprises by chemical metrology analysis. METHODS HPLC was used to establish fingerprint at 254 nm. Twenty-nine batches of products from nine enterprises were determined, and the quality of JYHFG of different batches was evaluated through similarity evaluation, clustering analysis (HCA) and principal component analysis (PCA). RESULTS Seventeen common peaks were confirmed in the HPLC fingerprint of 29 batches of JYHFG, and 10 of them were identified. The similarity of JYHFG was 0.84-0.99, and the samples could be grouped into one category according to enterprise, among which the characteristic peak of chlorogenic acid had the greatest influence on the fingerprint. CONCLUSION The establishment of HPLC fingerprint and the identification of chemical pattern provide a more comprehensive reference for the quality control of JYHFG. It provides a reliable method for scientific evaluation and effective quality control.
王赵, 王亚丹, 李静, 金红宇, 马双成. HPLC指纹图谱比较不同企业金银花配方颗粒质量差异[J]. 中国药学杂志, 2020, 55(8): 631-636.
WANG Zhao, WANG Ya-dan, LI Jing, JIN Hong-yu, MA Shuang-cheng. Quality Comparison of Jinyinhua Formula Granules from Different Enterprises Using HPLC Fingerprint. Chinese Pharmaceutical Journal, 2020, 55(8): 631-636.
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2020, Vol. 55 
