ZUO Wei-ping1, CAI Yu2, LIU Wen-ying3, WANG Dong-geng4*
1. People's Hospital of Funing County, Yancheng 224400,China; 2. Yancheng First People's Hospital, Yancheng 224005, China; 3. College of Pharmacy,China Pharmaceutical University, Nanjing 210009, China; 3. College of Pharmacy, Nantong University, Nantong 226001, China
Abstract：OBJECTIVE To study the chemical constituents from Polygonum cuspidatum. METHODS The petroleum ether-ethyl acetate solvents at different ratios of 9:1, 7:1, 5:1, 3:1 and 1:1 were used as gradient eluents for silica gel column chromatography, and samples collected were further isolated and purified by preparative high performance liquid chromatography. Their structures were elucidated by physico-chemical constants and spectroscopic methods. RESULTS Eight compounds were obtained and identified as 22(Z)-ergosterol-4,6,8,22-tetraene-3-one(1), (22E,24R)-stigma-1,4-diene-3-one(2), (E)-ethyl octadecanoic-16-enoic acid ethyl ester(3), oleanolic acid(4), emodin(5), resveratrol(6), trans-resveratrol glycoside(7) and 6'-gallic acid-4-O-D-resveratrol ester(8).CONCLUSION Compound 1 is a new natural compound (patent No. ZL 2013 10205435.5), compound 2 and 3 are isolated from this plant for the first time.
左卫平, 蔡昱, 刘文英, 汪冬庚. 虎杖化学成分研究[J]. 中国药学杂志, 2020, 55(3): 189-193.
ZUO Wei-ping, CAI Yu, LIU Wen-ying, WANG Dong-geng. Chemical Constituents from Polygonum cuspidatum. Chinese Pharmaceutical Journal, 2020, 55(3): 189-193.
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2020, Vol. 55 
