Research and Application of Chemical Marker Based on Q-marker Theory
LIN Yong-qiang1, LIN Lin1, JIAO Yang1, MU Xiang-rong1, GUO Dong-xiao1, WANG Bing1, WANG Shu-hua2*
1. NMPA Key Laboratory for Quality Evaluation of Gelatin Products, Shandong Provincial Insititute for Food and Drug Control, Jinan 250101, China; 2. NMPA Center for Drug Evaluation, Beijing 100022, China
Abstract：OBJECTIVE To explore a new research mode of TCM quality control, provide new ideas and perspectives for TCM quality control and research, improve the quality of TCM products, and promote the healthy development of TCM industry. METHODS Under the theoretical system of Q-marker proposed by academician LIU Chang-xiao, we put forward the concept of chemical markers, looking for sources of some medicinal herbs (slices) unique and not from other medicinal chemistry as a chemical Marker used for the identification and quality control of Chinese traditional medicine. RESULTS AND CONCLUSION Cynanchi Atrati Radix Et Rhizoma, Asini Corii Colla and Melanteritum were used as the representatives of plant medicine, animal medicine and mineral medicine respectively to study the chemical markers of genuine and fake products, and to apply them in the preparations such as Nvjin pill and Yigan jiedu capsule, which played an important role in the national drug evaluation sampling test.
林永强, 林林, 焦阳, 穆向荣, 郭东晓, 汪冰, 王淑华. 基于Q-Marker理论的化学标识物研究及应用[J]. 中国药学杂志, 2020, 55(2): 161-166.
LIN Yong-qiang, LIN Lin, JIAO Yang, MU Xiang-rong, GUO Dong-xiao, WANG Bing, WANG Shu-hua. Research and Application of Chemical Marker Based on Q-marker Theory. Chinese Pharmaceutical Journal, 2020, 55(2): 161-166.
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2020, Vol. 55 
