Research on Quality Control Methods of Panax ginseng, Panax quinquefolius, Panax notoginseng and Related Proprietary Chinese Medicines Based on Q-Marker
LIU Yong-li1, LEI Rong1, WANG Xiao-lei1, ZHAO Zhen-xia1, FENG Li1, WEI Feng2, MA Shuang-cheng2, LIU Chang-xiao3*
1. Hebei Institute for Drug Control, Shijiazhuang 050011, China; 2. National Institutes for Food and Drug Control, Beijing 100050, China; 3. National Engineering Laboratory for Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Research Center of Quality Markers of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
Abstract：OBJECTIVE To explore Q-markers of Panax ginseng, Panax quinquefolius, Panax notoginseng and establish the content determination method based on the concept and research model of Q-marker. METHODS The material basis and biosynthesis pathway of Panax ginseng, Panax quinquefolius, Panax notoginseng were analyzed. The main components of three medicinal materials were determined by liquid chromatography-mass spectrometry, and methods for determination of Q-markers in Panax ginseng, Panax quinquefolius, Panax notoginseng herbs and proprietary Chinese medicine were established. RESULTS The Q-markers of Panax ginseng, Panax quinquefolius, and Panax notoginseng were their specific constituents, including ginsenosides Rf, pseudo ginsenoside F11, notoginseng saponins R1, and the ratio feature of the common constituents, including ginsenosides Rg1, ginsenosides Re, and ginsenosides Rb1. METHODS for determination of Q-markers in Panax ginseng, Panax quinquefolius, Panax notoginseng herbs and proprietary Chinese medicine were established by ultra-high performance liquid chromatography (UPLC) and ultra-high performance liquid chromatography-electrospray ionization quadruple mass spectrometry (UPLC/MS/MS). CONCLUSION The Q-markers which were selected are scientific and reasonable, also can reflect the characteristics of the three medicinal materials. The established methods would improved the quality control level of Panax ginseng, Panax quinquefolius, Panax notoginseng and related proprietary Chinese medicine.
刘永利, 雷蓉, 王晓蕾, 赵振霞, 冯丽, 魏锋, 马双成, 刘昌孝. 基于中药质量标志物的人参、西洋参、三七及相关中成药质量控制方法研究[J]. 中国药学杂志, 2019, 54(17): 1402-1410.
LIU Yong-li, LEI Rong, WANG Xiao-lei, ZHAO Zhen-xia, FENG Li, WEI Feng, MA Shuang-cheng, LIU Chang-xiao. Research on Quality Control Methods of Panax ginseng, Panax quinquefolius, Panax notoginseng and Related Proprietary Chinese Medicines Based on Q-Marker. Chinese Pharmaceutical Journal, 2019, 54(17): 1402-1410.
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2019, Vol. 54 
