Pharmacokinetics and Imaging Effect of PET Bone Imaging Agent Sodium Fluoride
GUO Fei-hu1,CHEN Xue-qi2, LIU Meng2, XU Xiao-min1, FENG Ting-ting1, HUANG Xian-nan1, DU Jian-dong1, JIANG Hua1, CHENG Wei-hua1, WU Jian-shuang1, WANG Cheng-long1, LI Yan-tao1, LIANG Wei1, WANG Rong-fu2,3, FAN Hong-qiang1*, ZHANG Chun-li2*
1. High Tech of Atom Co., Ltd., Beijing 102413, China; 2. Peking University First Hospital, Beijing 100034, China; 3. Peking University International Hospital, Beijing 102206, China
Abstract：OBJECTIVE Sodium fluoride is a radioactive diagnostic agent for positron emission tomography (PET) indicated for imaging of bone to define areas of altered osteogenic activity. To investigate the pharmacokinetic properties of sodium fluoride, and to study its diagnostic effects by PET imaging. METHODS This study was focused on the preparation and the quality control of sodium fluoride injection, the blood clearance and plasma protein binding rate of sodium fluoride in New Zealand rabbits, the randomized controlled trial of sodium fluoride PET and 99Tcm-MDP SPECT imaging, and comparing of the imaging results. RESULTS Sodium fluoride was prepared, the test results conformed to the requirements of the quality control. The half-life of blood clearance phase was 37 min, the clearance rate in the body was 56 mL·min-1·kg-1, and the plasma protein binding rate was 0.57%. From both sodium fluoride PET and 99Tcm-MDP SPECT imaging, the whole body skeleton were visible. However, it only took 30 min for sodium fluoride to present excellent imaging with clearer bone after administration. The radioactive uptake ratio (T/NT) of sodium fluoride between the bone and the muscle was significantly higher than the T/NT of 99Tcm-MDP.CONCLUSION Sodium fluoride PET is superior to 99Tcm-MDP SPECT for bone imaging. This study provides an experimental basis for the clinical application of sodium fluoride PET in the bone imaging.
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2019, Vol. 54 
