1. Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China; 2. Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Abstract：OBJECTIVE To investigate the adsorption of insulin in total nutrient admixture solutions(TNA) in three different material disposable parenteral nutrition infusion bags and provide the reference for compounding of parenteral nutrition and clinical nutrition support. METHODS TNA were compounded according to consensus for parenteral nutrition solutions compounding containing same prescriptions and same dose of insulin in different materialsinfusion bags including polyvinyl chloride(PVC) and ethylene-vinyl acetate copolymer(EVA) and triple chambered bag(TCB). Determination of concentrations of insulin by HPLC for 0, 2, 4, 6, 8, 10, 12, 14, 15 h with infusion speed 40 drops·min-1(2 mL·min-1). RESULTS The RESULTS of determination in 7 groups of TNA samples at different time points were between 69.5% to 102.8% of the oretical value. The insulin concentrations was low at the initial stage (0 and 2 h, mean difference: 2.4-8.0 IU·L-1). The concentrations of insulin in 4-15 h was no significant difference. There was a significant difference in different material bags:TCBvs EVA (mean difference:2.4 IU·L-1, P=0.012). PVC vs EVA(mean difference:1.6 IU·L-1, P=0.020).CONCLUSION The adsorption of insulin in EVA material bags is significantly different from that in TCB and PVC, the concentrations of insulin in TNA of different material bags was low in the initial stage (0 and 2 h). There is no significant difference in the concentrations of insulin at 4-15 h. When TNA is compounding in EVA, PVC and KABI nutritional bags, insulin can be used as a way to supplement for patients daily needs.
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