Migraine is a kind of headache caused by abnormalities in the nervous system. According to neurovascular theory, migraine is associated with increased expression of calcitonin-related peptide (CGRP) in the surrounding tissues of the skull. Compared with traditional small molecule chemicals, biological drugs have the advantages of high specificity and low toxicity. We did a review of monoclonal antibodies therapies of migraine, focusing on CGRP and its receptor. Four drugs are on the market or in the clinical phase ��, namely erenumab, glcanezumab, fremanezumab, and eptinezumab. Some clinical trial results were summarized and three drugs on the market were compared. This article also discussed the limitations of monoclonal antibody drugs targeting CGRP and their future was prospected.
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