The Effect of Water-Soluble Excipients on the Inclusion Complex of Fenofibrate and Hydroxypropyl-��-Cyclodextrin
YE Jia-jie1, LU Jia-min2, ZHENG Meng-ke2,DING Xi-zhao1, ZHU Xing-yi1,2*
1. College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China; 2. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
Abstract��OBJECTIVE To study the effect of water-soluble materials on the inclusion complex of fenofibrate and hydroxypropyl-��-cyclodextrin. METHODS The inclusion complex of fenofibrate/hydroxypropyl-��-cyclodextrin and the ternary system containing water-soluble materials were obtained by ball milling. The inclusion complex was characterized by differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD), Fourier-transformed infrared spectrophotometry (FTIR), 1H-NMR spectroscopy, as well as in vitro dissolution and stability test. RESULTS The stability tests and in vitro dissolution results showed that the addition of water-soluble materials could improve the stability constant and inclusion efficiency of the inclusion complex. Moreover, the addition of hydroxypropyl methylcellulose(HPMC) could result in a more stable complex and the in vitro dissolution rate of complex was also increased. CONCLUSION The addition of appropriate water-soluble materials could enhance the inclusion efficiency of hydroxypropyl-��-cyclodextrin with drugs and form a more stable system.
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YE Jia-jie, LU Jia-min, ZHENG Meng-ke,DING Xi-zhao, ZHU Xing-yi. The Effect of Water-Soluble Excipients on the Inclusion Complex of Fenofibrate and Hydroxypropyl-��-Cyclodextrin. Chinese Pharmaceutical Journal, 2019, 54(10): 790-795.
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2019, Vol. 54 
