目的 研究壮药珠芽艾麻(Laportea bulbifera)的化学成分。方法 珠芽艾麻用体积分数60%乙醇提取,经硅胶、聚酰胺、Sephadex LH-20、ODS、重结晶、半制备HPLC进行分离纯化。结合理化性质、波谱数据鉴定化合物的结构。结果 从中分离出10个化合物,分别鉴定为β-谷甾醇(1),原儿茶酸乙酯(2),东莨菪亭(3),反式肉桂酸(4),(E)-对羟基肉桂酸(5),山柰酚-7-O-α-L-鼠李糖苷(6),木犀草素(7),没食子酸乙酯(8),(+)-异落叶松脂素-9-O-β-D吡喃葡萄糖(9)和山柰酚-3,7-α-L-二鼠李糖苷(10)。结论 化合物2,5,7~9为首次从艾麻属植物中分离得到,化合物2~5,7~9为首次从该植物中分离得到。
Abstract
OBJECTIVE To study the chemical constituents from Laportea bulbifera. METHODS The 60% ethanol extract from L. bulbifera was isolated and purified by chromatography on silica, Sephadex LH-20, and ODS, recrystallization, and semi-preparative HPLC. Their chemical structures were elucidated by physicochemical properties and spectroscopic methods. RESULTS These compounds were determined as β-sitosterol(1), protocatechuic acid ethyl ester(2), scopoletin (3), trans-cinnamic acid (4),trans-p-hydroxycinnamic acid(5), kaempferol 7-O-rhamnoside(6), luteolin(7), ethyl gallate(8), (+)-isolarisiresinol 3a-O-β-D-glucopyranoside(9), and kaempferitrin(10). CONCLUSION Compounds 2, 5, 7-9 are isolated from genus Laportea for the first time, and compounds 2-5,7-9 are isolated from this plant for the first time.
关键词
壮药 /
珠芽艾麻 /
化学成分 /
分离 /
鉴定
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Key words
Zhuang medicine /
Laportea bulbifera /
chemical constituents /
isolation /
identification
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中图分类号：
R284
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参考文献
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脚注
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基金
广西壮族自治区教育厅高校科研资助项目(YB2014192);
辽宁省特聘教授基金资助项目;
广西科学研究与技术开发计划资助项目(桂科攻14124002-11-1);
广西高等学校高水平创新团队及卓越学者计划资助项目-壮医基础与临床创新团队资助项目(桂教人〔2014〕07号)
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