Abstract��OBJECTIVE To establish the preparation technology of Moutan Cortex standard decoction and formula granules. METHODS Moutan Cortex standard decoction was prepared by decocting pot and the parameters and fingerprints of 15 batches of decoction were established.To improve the preparation process of Moutan Cortex formula granules, paeonol was quickly recovered by using volatile oil collection device in the process of vacuum concentration, and the collected paeonol was added back to the concent rated solution.Then, the formula granules of Moutan Cortex were prepared by spray drying and dry granulating.The correlation between the decoction pieces, extract, concentrate, powder, formula granules and standard decoction were compared by taking the contents of paeoniflorin, paeonol and fingerprint as indexes. RESULTS The range of parameters for Moutan Cortex standard decoction(70%-130% of the average value) were as follows:the dry extract rate was 19.46%-36.14%. The content of paeoniflorin was in the range of 1.83%-3.40%, and the transfer rate was 60.32%-100.00%. The content of paeonol was 1.25%-2.33%, and the transfer rate was 14.42%-26.78%.The contents of paeoniflorin and paeonol in the formula granules of Moutan Cortex conformed to the range of standard decoction parameters. CONCLUSION The parameters of Moutan Cortex standard decoctions prepared by decocting pot are confirmed, and a new preparation process of Moutan Cortex formula granules is established.Both of standard decoction and formula granules have good consistency in the contents of the index components,which could provide a certain scientific basis for the guidance of actual production.
CHUNNIAN H, YONG P, YUXIONG F, et al. Quick comparison of Radix Paeonia Alba, Radix Paeonia Rubra, and Cortex Moutan by high performance liquid chromatography coupled with monolithic columns and their chemical pattern recognition[J]. Pharmacogn Mag,2012,8(31):237-243.
[3]
CHEN S L, LIU A, LI Q, et al. Research strategies in standard decoction of medicinal slice[J]. China J Chin Mater Med(�й���ҩ��־),2016,41(8):1367-1375.
[4]
LI R, ZHAI H Q, TIAN W L, et al. Comparative analysis between origin of cooked traditional Chinese medicine powder and modern formula granules[J]. China J Chin Mater Med(�й���ҩ��־),2016,41(5):965-969.
[5]
CHEN S L. Standard Decoction of Chinese Herbal Medicine Vol��(��ҩ��Ƭ��������һ��)[M]. Beijing:Science Press,2018:2-22.
[6]
YANG R, ZHENGH Z. The general situation of modern researches in decocting the method of traditional Chinese medicine[J]. Chin Med Pharm(�й�ҽҩ��ѧ),2012,2(17):44-46.
[7]
TIAN Y R, ZHEN Y Q, WANG X G, et al. Assay and fingerprint chromatogram of scutellariabarbata formula granules by HPLC [J]. Chin Pharm J(�й�ҩѧ��־),2016,51(20):1795-1799.
[8]
JIAO M J, DENG Z, ZHANG J, et al. Study on preparation and quality standard of standard decoction of Chinese herbal medicine containing volatile components-a case study of Moutan Cortex[J]. China J Chin Mater Med(�й���ҩ��־),2018,43(5):891-896.
[9]
FENG W J, JIA X B, DAN L. Analysis on multi-factors affecting quality of Chinese materiamedica decoction and standardization of management [J]. J Chin Tradit Herb Drugs(�в�ҩ),2014,45(16):2422-2426.
[10]
WANG J, SHI D S, LIU B, et al. Comparative study on different processes for Chinese materia medica Moutan Cortex and Cinnamomi Cortex formula granules containing volatile components [J]. Chin Tradit Herb Drugs(�в�ҩ),2015,46(24):3687-3690.
2018, Vol. 53 
