Comparative Study on the Immune Enhancement and Anti-aging Activities between Cultivated and Wild Cordyceps sinensis
ZHENG Jian1, HUO Xiao-kui2, WANG Yan2, GUO Li-nong1, LIU Jie1, ZAN Ke1, MA Xiao-chi2*, MA Shuang-cheng1*, QIAN Zheng-ming3, LI Wen-jia3
1. National Institutes for Food and Drug Control, Beijing 100050, China; 2. Dalian Medical University, Dalian 116044, China; 3. Guangdong Dongyanggaung Pharmaceutical Co., Ltd., Dongguan 523808, China
Abstract��OBJECTIVE To observe the immune enhancement and anti-aging activities of cultivated and wild Cordyceps sinensis. METHODS Mice were randomly divided into seven groups: high dose cultivated Cordyceps sinensis group, low dose cultivated Cordyceps sinensis group, high dose wild Cordyceps sinensis group, low dose wild Cordyceps sinensis group, control group, model group and positive drug group. Immunosuppression mouse model were induced by cyclophosphamide and the physical status, carbon clearance capacity, phagocytosis coefficient and lymphocyte transformation stimulation index, and ear swelling of mice were observed. The aging mice model was established by subcutaneously injecting D-galactose, and brain histology, antioxidant and anti-inflammatory capacity of mice were observed. RESULTS Both cultivated and wild Cordyceps sinensis increased the body weight and immune organ index, and enhanced the immunity of the mice. Furthermore, both cultivated and wild Cordyceps sinensis ameliorated the pathological changes in brain histology, and enhanced the antioxidant and anti-inflammatory ability of the mice. There was no obvious difference in the immune enhancement and anti-aging activities between cultivated and wild Cordyceps sinensis. CONCLUSION Both cultivated and wild Cordyceps sinensis can improve immunity and retard the aging process. Cultivated Cordyceps sinensis can be used as the alternative choice of wild Cordyceps sinensis in clinic.
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ZHENG Jian, HUO Xiao-kui, WANG Yan, GUO Li-nong, LIU Jie, ZAN Ke, MA Xiao-chi, MA Shuang-cheng, QIAN Zheng-ming, LI Wen-jia. Comparative Study on the Immune Enhancement and Anti-aging Activities between Cultivated and Wild Cordyceps sinensis. Chinese Pharmaceutical Journal, 2018, 53(20): 1742-1747.
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2018, Vol. 53 
