目的 研究中药枳壳(Citrus aurantium L.)的化学成分。方法 采用甲醇提取,应用现代色谱技术分离纯化,依据化合物理化性质和光谱数据鉴定化合物结构。结果 从中药枳壳体积分数95%甲醇提取物中分离鉴定了16个化合物,分别为:pyrrolezanthine-6-methyl ether(1),3-羟基-4-甲氧基苯甲酸甲酯(2),3-羟基-4-甲氧基苯甲酸(3),3,4-二羟基苯甲酸甲酯(4),3-(4-乙酰氧基苯基)丙酸酯(5),对羟基苯甲酸(6),7-羟基-6-甲氧基香豆素(7),5-羟甲基呋喃-2-甲醛(8),橙皮苷(9),柚皮苷(10),gossypetin-8,3'-dimethylether-3-O-β-D-galactosid(11),2-homoeriodictyol-7-O-β-D-glucopyranoside(12),6-去甲氧基桔皮素(13),柚皮素(14),红橘素(15)和5-O-去甲基川陈皮素(16)。结论 化合物1、2、4、8、11~13均为首次从该属植物中分离得到。
Abstract
OBJECTIVE To study the chemical constituents of Citrus aurantium L. METHODS Chromatographic techniques were employed for isolation and purification of the constituents and their structures were determined by spectral analysis and chemical evidence. RESULTS Sixteen compounds were obtained and identified as pyrrolezanthine-6-methyl ether (1), methyl 3-hydroxy-4-methoxybenzoate (2), 3-hydroxy-4-methoxybenzoic acid (3), methyl 3,4-dihydroxybenzoate (4), methyl 3-(4-acetoxyphenyl)propanoate (5), 4-hydroxybenzoic acid (6), scopoletin (7), 5-(hydroxymethyl)furan-2-carbaldehyde (8), hesperidin (9), naringin (10), gossypetin-8,3'-dimethylether-3-O-β-D-galactoside (11), 2-homoeriodictyol-7-O-β-D-glucopyranoside (12), 6-demethoxytangeretin (13), naringenin (14), 5,6,7,8,4'-pentamethoxyflavone (tangeretin) (15), and 5-O-desmethylnobiletin (16). CONCLUSION Compounds 1、2、4、8、11-13 are for the first time obtained from Citrus.
关键词
中药枳壳 /
化学成分 /
结构鉴定
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Key words
Citrus aurantium L /
chemical constituents /
structural identification
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中图分类号：
R284
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脚注
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基金
国家自然科学基金地区项目资助(31660094);江西省自然科学基金面上项目资助(20161BAB204179)
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