微针透皮递药系统研究进展

鲁洋, 程祝强, 金毅, 丁智

中国药学杂志 ›› 2018, Vol. 53 ›› Issue (12) : 945-950.

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中国药学杂志
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中国药学杂志 ›› 2018, Vol. 53 ›› Issue (12) : 945-950. DOI: 10.11669/cpj.2018.12.001
·综述·

微针透皮递药系统研究进展

  • 鲁洋1, 程祝强2, 金毅2*, 丁智1,3*
作者信息 +

Research Updates on Microneedle-Based Transdermal Drug Delivery Systems

  • LU Yang1, CHENG Zhu-qiang2, JIN Yi2*, DING Zhi1,3*
Author information +
文章历史 +

摘要

微针透皮给药系统是指利用微针穿刺皮肤角质层形成微小孔道,无痛或微痛地促进药物经皮渗透的一种给药策略。微针给药技术作为一种新型的透皮给药方式,与单独使用透皮制剂相比,可以显著提高药物透皮吸收的效率,扩大经皮递药适用的药品种类,促进水溶性药物的透皮吸收和提高大分子药物透皮的能力,使药物在体内更好地发挥作用。微针技术在透皮给药领域发展迅速,笔者通过对近年来国内外微针技术应用于透皮递药方面的代表性文献进行归纳总结,将微针技术在透皮递药领域的最新进展呈现给读者。

Abstract

Microneedle-based transdermal drug delivery system refers to the use of microneedles piercing the stratum corneum of the skin to form tiny pores, through which drug absorption via the skin is enhanced with minimal pain sensation. As a novel drug delivery method, the microneedle technology can significantly improve the transdermal absorption efficiency of the drugs, especially hydrophilic drugs, as compared with using transdermal drug formulations alone. Thus the scope of applicable drugs for transdermal delivery are remarkably enlarged, the efficacy and bioavailability improved as well. Microneedle technology has developed rapidly in the field of transdermal drug delivery. In this paper, the recent representative literature on microneedle-aided transdermal drug administration home and abroad to present the latest progress in this field that was summarized.

关键词

微针 / 透皮递药 / 疫苗

Key words

microneedle / transdermal drug delivery / vaccine

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导出引用
鲁洋, 程祝强, 金毅, 丁智. 微针透皮递药系统研究进展[J]. 中国药学杂志, 2018, 53(12): 945-950 https://doi.org/10.11669/cpj.2018.12.001
LU Yang, CHENG Zhu-qiang, JIN Yi, DING Zhi. Research Updates on Microneedle-Based Transdermal Drug Delivery Systems[J]. Chinese Pharmaceutical Journal, 2018, 53(12): 945-950 https://doi.org/10.11669/cpj.2018.12.001
中图分类号： R944   

参考文献


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基金

中央军委后勤保障部卫生局军事医学创新工程项目资助(CNJ16J009);江苏省自然科学基金面上项目资助(BK20161478)
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