Research Updates on Microneedle-Based Transdermal Drug Delivery Systems
LU Yang1, CHENG Zhu-qiang2, JIN Yi2*, DING Zhi1,3*
1. School of Life Sciences, Nanjing University, Nanjing 210023, China; 2. Pain Management, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China; 3. Institute of Biopharmaceutical Technology, Changzhou Institute of Industrial Technology, Nanjing University, Changzhou 213164, China
Abstract��Microneedle-based transdermal drug delivery system refers to the use of microneedles piercing the stratum corneum of the skin to form tiny pores, through which drug absorption via the skin is enhanced with minimal pain sensation. As a novel drug delivery method, the microneedle technology can significantly improve the transdermal absorption efficiency of the drugs, especially hydrophilic drugs, as compared with using transdermal drug formulations alone. Thus the scope of applicable drugs for transdermal delivery are remarkably enlarged, the efficacy and bioavailability improved as well. Microneedle technology has developed rapidly in the field of transdermal drug delivery. In this paper, the recent representative literature on microneedle-aided transdermal drug administration home and abroad to present the latest progress in this field that was summarized.
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