ժҪ ��֭���л����(the metabolic profile of bile acid,MPBA)�Ƿ�ӳ�������ڵ�֭�����ࡢ�������仯��ָ�ꡣͨ�����ּ�⼼���ⶨ������֯�����еĵ�֭��(bile acids, BAs)�ɹ�������Ӧ��MPBA,���ڸε�������θ������������л�Լ����Լ���ϵͳ�ȼ����о���һ��Ӧ�á����ع����ܽ���BAs��л����,������ͬ��֯��BAs�ļ�⼼��,������MPBA����ؼ�������������е�Ӧ�á�MPBA�ڼ�������Լ���Ч���۵ȷ������һ��������,ֵ�ý�һ�������о���
Abstract��The metabolic profile of bile acids (MPBA) is an indicator that reflecting the varieties, contents and variations of biological bile acids (BAs). Many kinds of detection techniques can be used to detect different kinds of BAs in different tissues. By using various detection techniques, the MPBA has been applied in various diseases such as hepatobiliary diseases, gastrointestinal diseases, metabolic diseases and nervous system diseases and so on. In this paper, we reviewed the process of BAs synthesis and metabolism and analyzed the detection techniques of BAs in different tissues and the corresponding MPBA. At the same time, we summarized the application of BAs metabolism in related diseases. The MPBA provides a reference for the diagnosis and treatment of some diseases and it has certain advantages in disease diagnosis and curative effects evaluation, which worth further study.
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LEI Kai, ZHANG Cheng-liang, LIU Ya-nan, REN Xiu-hua, LIU Dong. Research Progress and Application of Metabolite Profiling of Bile Acids. Chinese Pharmaceutical Journal, 2018, 53(2): 92-97.
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2018, Vol. 53 
