Abstract��OBJECTIVE To study the anti-obesity effect of crude extract of okra on nutrition-obese mice. METHODS The fifty SPF ICR male mice were randomly divided into five groups:control(0.9% normal saline), model(0.9% normal saline), okra alcohol extraction high, medium and low dose group(400, 200, 100 mg��kg-1). In addition to the mice in control group, the mice in other four groups were given high fat diet to make the model of obese mice, after oral administration for 4 weeks, eyeball blood of the mice was taken to measure the contents of serum triglyceride(TG), total cholesterol(TC), leptin(LEP), adiponectin(ADP), high density lipoprotein(HDL-C), and low density lipoprotein(LDL-C). Then mice were sacrificed to take their liver tissue and fat to detect the expression of SREBP-1 and FAS mRNA by RT-PCR. RESULTS Compared with the model, the okra alcohol extract could effectively decrease the contents of TC, TG, LDL-C and LEP, increase the contents of HDL-C and ADP(P��0.01,P��0.05), improve the dyslipidemia, and regulate the secretion of protein in adipose tissue, to achieve the therapeutic effect on obese mice. The expressions of SREBP-1 and FAS mRNA were also significantly inhibited by crude extract of okra. CONCLUSION The results show that treatment of crude extract of okra on obese mice is associated with the expressions of SREBP-1 and FAS.
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LI Ying, ZENG Lu-lu, GAO Ming-tong,HOU Wei,SUN Meng, ZHU Lin, LIU Wen-cong, DING Chuan-bo, ZHENG Yi-nan. Anti-obesity Effects of Alcohol Extract from Abelmoschus esculentus Linn. and Its Correlation with Gene SREBP-1 and FAS. Chinese Pharmaceutical Journal, 2017, 52(23): 2087-2091.
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