Abstract��OBJECTIVE To study the effect and action mechanism of the large plant Rhodiola Tablet on myocardial ischemia of rats. METHODS Rat myocardial ischemia models were induced by coronary artery ligation. The levels of AST, ALT, CK and CK-MB in serum were observed, at the same time the expressions of B-raf, Ras and p-ERK1/2 in myocardial tissue were determined. RESULTS The levels of AST, ALT, CK and CK-MB in rat serum, as well as the B-raf, Ras and p-ERK1/2 expression in rats myocardium in the large plant Rhodiola group were significantly lower than that in the model group. CONCLUSION Large plant Rhodiola has a certain antagonism on myocardial ischemia injury in rats caused by coronary artery ligation. The mechanism of action may be related to the decreases in serum AST, ALT, CK and CK-MB,as well as myocardial high expression of the B-raf, Ras and p-ERK1/2.
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LI Zhuo-qiong, LI Fang, ZHOU Jun,CAO Liang,CAO Ze-yu, HUANG Wen-zhe, WANG Zhen-zhong,XIAO Wei. Effects and Mechanisms of Large Plant Rhodiola Tablet on Acute Myocardial Ischemia of Rats. Chinese Pharmaceutical Journal, 2017, 52(22): 1993-1997.
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2017, Vol. 52 
