Abstract��OBJECTIVE To optimize the formulation of avilamycin self-microemulsifying drug delivery system (SMEDDS)using central composite design-response surface method and evaluate its quality. METHODS The compositions of avilamycin SMEDDS were screened by solubility experiment and self-emulsifying grading test. The formulation was optimized using Design Expert Software, taking particle size and Zeta potential as dependent variables and the usage amounts of oil, surfactant and cosurfactant as independent variables. RESULTS The optimized formulation was quickly and conveniently obtained as follows:36.67% propylene glycollaurate, 42.83% cremophor RH40 and 20.50% diethylene glycol monoethyl ether.The average diameter of the preparation was (28.34��0.06)nm, the Zeta potential was (-1.98��0.24)mV and PDI was (0.15��0.005). CONCLUSION The central composite design and response surface method is useful for the formula optimization of avilamycin self-microemulsifying drug delivery system.The prediction accuracy of the established mode1 is good.
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2017, Vol. 52 
