a. Department of Pharmacy, Ministry of Education Key Laboratory of Child Development and Disorders; b. Department of Hematology, Children��s Hospital of Chongqing Medical University, Chongqing 400014, China
Abstract��OBJECTIVE To establish pediatric-focused trigger of adverse drug event using Delphi expert consensus method,and provide a reference for clinical to develop ADE active monitoring based on GTT. METHODS The formed trigger items were adopted to design an expert consultation questionnaire based on GTT white paper,related literatures and by expert pre investigation. Twenty-seven experts from Beijing��Shanghai and so on were chosen to do a two-round Delphi consultation. Trigger items were screened and modified.RESULTS THE recovery rate of questionnaire were 92.6%��100%. After two rounds of consultation the authority coefficient (Cr) was 0.81��0.05. The coefficient of variation (CV) was 0.29��0.13. The KendallW was 0.346, respectively(P<0.001). Finally 36 trigger items were formulated,including 20 laboratory index, 9 antidotes, 4 clinical symptoms and 3 intervention measures.CONCLUSION It is reasonable, feasible to adopt Delphi expert consensus method as pediatric-focused trigger of adverse drug events,which lays the foundation for the implementation of GTT.
�����������֣�Ф���ģ�����������ѧ�ģ����ݣ�������. ���õ¶��Ʒ���������ȫ�津�����߷��Ķ�ͯҩƷ�����¼�������[J]. �й�ҩѧ��־, 2017, 52(2): 157-161.
JI Huan-huan,SONG Lin, XIAO Jian-wen, TIAN Xiao-jiang,TANG Xue-wen,GU Rong, JIA Yun-tao. The Established of Pediatric-Focused Adverse Drug Event Triggers based on GTT by using Delphi Method. Chinese Pharmaceutical Journal, 2017, 52(2): 157-161.
GAO X, LI Z P. The influence of medical staff��s personnel professionality on the pediatric ADR reporting rate in 236 hospitals . Chin Pharm J(�й�ҩѧ��־), 2015,50 (20):182-186.
[2]
GRIFFIN F A,RESEAR R K. IHI Global Trigger Tool for Measuring Adverse Events. 2nd ed. Cambridge, MA:Institute for Healthcare Improvement, 2009:18-29.
[3]
LI L, LIU T T,JIANG X. The use of global trigger tool for evaluating adverse drug events in hospitalized patients . ADR J, 2015,17 (4):164-167.
[4]
LIU J M,RAN S Y,LIU C, et al. Pilot study of detecting adverse drug events with Global Trigger Tool . Adverse Drug React J, 2014,16 (4):198-204.
[5]
TAKATA G S, MASON W, TAKETOMO C,et al. Development, testing, and findings of a pediatric-focused trigger tool to identify medication-related harm in US children��s hospitals. Pediatrics,2008,121 (4):e927-e935.
[6]
STOCKWELL D C, BISARYA H, CLASSEN D C,et al. A trigger tool to detect harm in pediatric inpatient settings. Pediatrics,2015,135 (6):1036-1042.
[7]
KIRKENDALL E S, KLOPPENBORG E, PAPP J,et al. Measuring adverse events and levels of harm in pediatric inpatients with the Global Trigger Tool. Pediatrics, 2012,130 (5):e1206-e1214.
[8]
SOLEVAG A L,NAKSTAD B. Utility of a paediatric trigger tool in a Norwegian department of paediatric and adolescent medicine. BMJ Open, 2014,4 (5):e005011.
[9]
ROZENFELD S, GIORDANI F, COELHO S. Adverse drug events in hospital: pilot study with trigger tool. Rev Saude Publica, 2013,47 (6):1102-1111. DONG Y J, LI B H, HOU S X. The establishment of transitional care program for discharged stroke patients using Delphi method . Chin Nursing Management, 2013,13(10):34-37. WANG C Z,SI Q. A study of data statistical processing method of Delphi method and its application. Edit Depart Inner Mongol Univ Finance Economics,2011,9 (4):92-96.
2017, Vol. 52 
