WANG Zheng1, ZOU Jian-jun2, LI Zhe1, SHEN Su1, YU Jun-xian1*
1. Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; 2. Department of New Drug Research and Development,Jiangsu Hengrui Medicine Co.,Ltd, Shanghai 200122, China
Abstract��Colorectal cancer is a common gastrointestinal cancer which always diagnosed too late. However, nowadays the median survival of patients has been effectively improved by chemotherapy plus targeted therapy. Targeted drugs on the market can be divided into two categories, monoclonal antibodies and small molecule kinase inhibitors(TKI). Bevacizumab, cetuximab, panitumumab, ramucirumab are monoclonal antibody. TKIs are as followed:regorafenib, ziv-aflibercept.According to the drug mechanism, bevacizumab and panitumumab target at epidermal growth factor receptor(EGFR)on tumor cells. While the remaining four drugs target at vascular endothelial growth factor(VEGF) and its receptor(VEGFR). Clinical trials of Chinese domestic drugs apatinib and famitinib are undergoing. Currently, the main issue of colorectal cancer targeted therapy is how to overcome drug resistance and reducetoxicity. The direction of future work is finding new targets, new drugs in colorectal cancer, such as PD-1 inhibitors which may bring new vitality to worldwide patients.
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