Abstract��OBJECTIVE To prepare docetaxel liposomes by freeze-drying of tert-butyl alcohol (TBA)/water cosolvent system and evaluate the in vitro and in vivo properties. METHODS The formulation was optimized by single factor screening experiments. The effects of TBA/water ratio, lipid/drug ratio, sucrose/lipid ratio and mixing temperature on encapsulation efficiency were investigated. The in vitro release profiles were also investigated with docetaxel injection(Duopafei�k) as control. RESULTS The formulated liposomes had a mean size of 263 nm with entrapment efficiency of (88.45��1.63)% at TBA/water ratio 50��50, lipid/ drug ratio 10��1, sucrose/lipid ratio 5��1 and mixing temperature 60 ��. In vitro drug release from liposomes lasted for 48 h. CONCLUSION Freeze-drying of TBA/water cosolvent system method may be feasible to prepare docetaxel liposomes.
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LI Fei, WANG Jian-zhu, BI Yan-ping, LIU Hui, ZHAO Qing-yuan. Preparation of Docetaxel Liposomes by Freeze-Drying of Tert-Butyl Alcohol/water Cosolvent System. Chinese Pharmaceutical Journal, 2016, 51(4): 293-297.
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2016, Vol. 51 
