Abstract��OBJECTIVE To investigate the correlation between serum HCY and blood pressure, discuss folic acid application time in patients with high HCY, and provide the reference about the use of folic acid for clinic pharmacists. METHODS Overall 147 patients enrolled in our hospital in January and June 2014 were included in the investigation. Disease distribution of patients with folic acid treatment was observed. According to<10 ��mol��L-1, 10 ��mol��L-1��HCY<15 ��mol��L-1,��15 ��mol��L-1, patients were divided into three groups to evaluate the difference of ages, serum creatinines, systolic pressures(SBP) and diastolic pressures(DBP). RESULTS In 43 patients taking folic acid with HCY>10 ��mol��L-1, 76.19% is combined with stroke, 16.67% with hypertension, and 7.14% with hyperhomocysteinemia. In patients without folic acid, about 78.10% is combined with HCY>10 ��mol��L-1, 28.05% with stroke,47.56% with hypertension, and 24.39%onlywith hyperhomocysteinemia. There were no significant differences in different HCY groups, P=0.796,0.784 respectively. But the level of serum creatinine was statisfically higher in HCY��15 ��mol��L-1 group than other 2 groups(P=0.004,0.034). And the age of patients in HCY��15 ��mol��L-1 group was also much higher than HCY<10 ��mol��L-1 group(P=0.029). There were no differences between other groups.CONCLUSION For patients with high HCY, the use of folic acid for stroke prevention is necessary, which is independent from blood pressure. Yet it is not necessary to take folic acid in patients who has suffered stroke or TIA. Elder and/or renal dysfunction patients with high HCY should be more actively to reduce HCY level.
����,�ƍ�,������,�˰�,����,ë��,��Ө,����. Ҷ���ڸ�ͬ�Ͱ��װ���Ѫ֢��Ӧ��ʱ���Ļع��Է���[J]. �й�ҩѧ��־, 2015, 50(10): 905-908.
ZHAO Li, TANG Kun, GUO Dong-jie, DENG Ang, KONG Xu-dong, MAO Min, LIU Ying, LIU Xiao. Retrospective Analysis of Folic Acid Application Time in Hyperhomocysteinemia Patients. Chinese Pharmaceutical Journal, 2015, 50(10): 905-908.
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