Abstract��OBJECTIVE To evaluate the current clinical application of ambroxol hydrochloride injection and promote its rational use. METHODS Based on the Hospital Prescription Analysis Cooperation Project, 160-day prescription data about ambroxol hydrochloride injection from 2010 to 2013 was sampled randomly from the database of 82 general hospitals in six cities including Beijing, Shanghai, Guangzhou, Hangzhou, Chengdu, and Tianjin. According to the drug instruction, relevant guidelines, expert consensus, and literature, the clinical use of ambroxol hydrochloride injection was analyzed. RESULTS Within the scope of sampling time, there were 2.67 million prescriptions of ambroxol hydrochloride injection, and 14.01 million ampoules(15 mg per ampoule) were used clinically. According to the percentage of prescription complying with the drug instruction, the six cities were ranked in descending order as follows:Hangzhou(28.03%) > Chengdu(26.25%) > Shanghai(14.66%) > Guangzhou(9.38%) > Beijing(7.72%) > Tianjin(3.98%). However, various off-label uses were found in administration route, dosage, and indications. CONCLUSION Off-label use of ambroxol hydrochloride injection is common in clinic, which needs to be paid great attention to and to be standardized.
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FAN Qian-qian, ZHANG Bo, LI Da-kui, MEI Dan(. Current Clinical Application of Ambroxol Hydrochloride Injection and Consideration on the Rational Drug Use. Chinese Pharmaceutical Journal, 2015, 50(9): 816-820.
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