Rescent Progress in Research on Prevention Strategy for Toxicity of Arsenic Trioxide Injection
XU Ying, LI Zhe,GONG Dong-mei,BAN Tao,SUN Gui-yuan, BAI Yun-long
Department of pharmacology, Harbin Medical University, Bio-pharmaceutical-engineering KeyLaboratory of Heilongjiang Province-Incubator of State Key Laboratory, Harbin 150081, China
Abstract��It is well known that arsenic is a kind of carcinogen which can induce a variety of cancers.Nevertheless, arsenic trioxide,one of its derivatives,served as a very promising anti-cancer agent, which has a significant effect on acute promyelocytic leukemia and a variety of tumors.However, the severe toxicity of arsenic trioxidel imited its clinical application. Therefore, more attentions have been paid on how to attenuate the side effect during arsenic trioxide treatment.Now, there are some solutions about this problem such as a good administration, drug combination, a suitable formulations, etc.This paper reviewed the laboratory and clinical research on the prevention of the toxicity of arsenic trioxidy.
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XU Ying, LI Zhe,GONG Dong-mei,BAN Tao,SUN Gui-yuan, BAI Yun-long. Rescent Progress in Research on Prevention Strategy for Toxicity of Arsenic Trioxide Injection. Chinese Pharmaceutical Journal, 2015, 50(11): 921-924.
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2015, Vol. 50 
