新型聚合物胶束及其在肿瘤治疗中的应用

杨舒迪,张学农

中国药学杂志 ›› 2015, Vol. 50 ›› Issue (12) : 1006-1011.

PDF(1891 KB)
PDF(1891 KB)
中国药学杂志 ›› 2015, Vol. 50 ›› Issue (12) : 1006-1011. DOI: 10.11669/cpj.2015.12.003
综述

新型聚合物胶束及其在肿瘤治疗中的应用

  • 杨舒迪,张学农*
作者信息 +

New Polymer Micelles and Its Application in Cancer Therapy

  • YANG Shu-di, ZHANG Xue-nong*
Author information +
文章历史 +

摘要

当前肿瘤化疗药物普遍存在低效高毒的缺点,选择合适的新剂型治疗肿瘤已成为重要的任务之一。本文利用肿瘤细胞内部的微环境特点,制备多种新型智能化聚合物胶束,可实现有效控制药物释放,毒副作用小,体内外疗效好的特点,具有很好的发展和应用前景。笔者以国内外研究文献为基础,简述聚合物胶束的构成、特点及主要制备方法,分类介绍了多种刺激响应性聚合物胶束,以及多种靶向聚合物胶束用作抗癌药物载体。

Abstract

The current prevalence of cancer chemotherapy drugs is inefficient and highly toxic, thus selecting the appropriate new forms of cancer treatment has become one of the important tasks. On the basis of domestic and foreign research literature, cutline the composition, characteristics and main preparation methods of polymeric micelles. Introduced varieties of stimuli-responsive polymer micelles, as well as targeted polymeric micelles used as an anticancer drug carrier. By making use of inside microenvironment of tumor cells, the preparation of various of new intelligent polymeric micelles with slight side effects and good treatment in virto and in vivo, can achieve effective control of drug release, which has great development and prospect in application.

关键词

聚合物胶束 / 响应性 / 载体 / 抗肿瘤 / 靶向

Key words

polymeric micelle / stimuli-responsive / carrier / anticancer / target

引用本文

导出引用
杨舒迪,张学农. 新型聚合物胶束及其在肿瘤治疗中的应用[J]. 中国药学杂志, 2015, 50(12): 1006-1011 https://doi.org/10.11669/cpj.2015.12.003
YANG Shu-di, ZHANG Xue-nong. New Polymer Micelles and Its Application in Cancer Therapy[J]. Chinese Pharmaceutical Journal, 2015, 50(12): 1006-1011 https://doi.org/10.11669/cpj.2015.12.003
中图分类号: R944   

参考文献

[1] BADER H, RINGSDORF H, SCHMIDT B. Water soluble polymers in medicine. Die Angewandte Makromolekulare Chemie, 1984, 123(1) :457-485.
[2] XU X Y, LI L, ZHOU J P. Advances on the research of doxorubicin loaded polymeric micelles .Chin J New Drugs(中国新药杂志),2007, 16(1):28-32.
[3] LEE E S, NA K, BAE Y H.Super pH-sensitive multifunctional polymericmicelle. Nano Lett, 2005,5 (2) :325-329.
[4] BASILE L, PIGNATELLO R, PASSIRANI C. Active targeting strategies for anticancer drug nanocarriers . Curr Drug Deliv, 2012,9(3): 255-268.
[5] KATAOKA K, HARADA A, NAGASAKI Y. Block copolymer micelles for drug delivery: Design, characterization and biological significance. Adv Drug Deliv Rev, 2001, 47(1): 113-131.
[6] GREF R, DOMB A, QUELLEC P, et al. The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. Adv Drug Deliv Rev , 1995,16(2-3):215-233.
[7] CHEN H, ZHANG T, ZHOU Z, et al. Enhanced uptake and cytotoxity of folate-conjugated mitoxantrone-loaded micelles via receptor up-regulation by dexamethasone. Int J Pharm, 2013, 448(1): 142-149.
[8] TORCHILIM V P. Structure and design of polymeric surfactant-based drug delivery systems . J Controlled Release, 2001, 73(2-3): 137-172.
[9] NICHOLASI L, SUDHIR M, XIAO J W, et al. Polymer nano-encapsulation of templated mesoporous silia monoliths with improved mechanical properties . Non-Crystalline Solids, 2008, 354(2-9): 632-644.
YOO H S, PARK T G. Biodegradable polymeric micells composed od doxorubicin conjugated PLGA-PEG block copolymer. J Controlled Release, 2001, 73(1-2): 63-70.
SONG Z, FENG R, SUN M, et al.Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo. J Colloid Interface Sci, 2011, 354(1): 116-123.
WANG X L, LIU C G. The study of pH-responsive nanoparticles based on hyaluronic acid as drug delivery system.Chin J New Drugs(中国新药杂志), 2010, 19(21): 1958-1963.
BAE Y, NISHIYAMA N, FUKUSHIMA S, et al. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjugate Chem, 2004, 16(1) : 122-130.
OSADA K, CHRISTIE R J, KATAOKA K. Polymeric micelles from poly (ethylene glycol)-poly (amino acid) block copolymer for drug and gene delivery. J Royal Soc Interface, 2009, 6: 325-339.
RAINA S, MISSIAKAS D. Making and breaking disulfide bonds . Annu Rev Microbiol, 1997, 51: 179-202.
KURTOGLU Y E, NAVATH R S, WANG B, et al. Poly (amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery . Biomaterials, 2009, 30(11): 2112-2121.
KIM J, SAHAY G, KABANOV A V, et al. Polymeric micelles with ionic cores containing biodegradable cross-links for delivery of chemotherapeutic agents . Biomacromolecules, 2010, 11(4): 919-926.
CHENG R, MENG F, DENG C, et al. Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery . Biomaterials, 2013, 34(14): 3647-3657.
KIM J, GARRIPELLI V K, JEONG U, et al. Novel pH-sensitive polyacetal-based block copolymers for controlled drug delivery. Int J Pharm, 2010, 401(1-2): 79-86.
WANG Y, BYRNE J D, NAPIER M E, et al. Engineering nanomedicines using stimuli-responsive biomaterials. Adv Drug Deliv Rev, 2012,64(11): 1021-1030.
PENG C L, TSAI H M, YANG S J, et al. Development of thermosensitive poly( n-isopropylacrylamide-co-( ( 2-dimethylamino) ethylmethacrylate))-based nanoparticles for controlled drug release. Nanotechnology, 2011, 22(26): 265608.
DAI J, LIN S, CHENG D, et al. Interlayer-crosslinked micelle with partially hydrated core showing reduction and pH dual sensitivity for pinpointed. Angew Chem Int Ed Engl, 2011, 50(40) : 9404-9408.
DAI J, LIN S, CHENG D,et al. Interlayer-crosslinked micelle with partially hydrated core showing reduction and pH dual sensitivity for pinpointed intracellular drug release. Angew Chem Int Ed, 2011, 50(40): 9404-9408.
LI W, FENG S S, GUO Y J. Block copolymer micelles for nanomedicine. Nanomedicine, 2012, 7(2): 169-172.
TIAN Y, MAO S R. Amphiphilic polymeric micelles as the nanocarrier for peroral delivery of poorly soluble anticancer drugs. Expert Opin Drug Del, 2012, 9(6): 687-700.
JIN Q J, YAN F, HONG M W, et al.Synthesis and micellization of photosensitive amphiphilic comblike SMA polymer. Acta Phys Chim Sin, 2008, 24(11): 2089-2095.
XIONG J M F, WANG C, CHENG R, et al. Folate-conjugated crosslinked biodegradable micelles for receptor-mediated delivery of paclitaxel. J Mater Chem, 2011, 21(24): 5786-5794.
BASILE L, PIGNATELLO R, PASSIRANI C. Active targeting strategies for anticancer drug nanocarriers. Curr Drug Deliv, 2012, 9(3): 255-268.
SHEN Y, JIN E, ZHANG B, et al. Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery. J Am Chem Soc, 2010, 132:4259-4265.
YANAGAWA T, NAKAMURA H, TAKEI I, et al. Klebsiella pneumoniae meningitis associated with liver abscess: A case report. Jpn J Antibiot, 1989, 42(22): 2135-2140.
TYRRELL Z L, SHEN Y Q, RADOSZ M. Fabrication of micellar nanoparticles for drug delivery through the self-assembly of block copolymers. Prog Polym Sci, 2010, 35(9): 1128-1143.
WU D Q, LU B, CHANG C, et al. Galactosylated fluorescent labeled micelles as a liver targeting drug carrier. Biomaterials, 2009, 30(7): 1363-1371.
BEI Y Y, YUAN Z Q, ZHANG L, et al. Novel self-assembled micelles based on palmitoyl-trimethyl-chitosan for efficient delivery of harmine to liver cancer. Exp Opin Drug Deliv, 2014, 11(6): 843-854.
DANHIER F, FERON O, PREAT V. To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Controlled Release, 2010, 148(2): 135-146.
NIKANJAM M, GIBBS A R, HUNT C A, et al. Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle. J Controlled Release, 2007, 124(3): 163-171.
ZHANG C, ZHU Q, ZHOU Y, et al. N-Succinyl-chitosan nanoparticles coupled with low-density lipoprotein for targeted osthole-loaded delivery to low-density lipoprotein receptor-rich tumors. Int J Nanomed, 2014, 9: 2919-2932.
BROWN M S, HERZ J, GOLDSTEIN J L. LDL-receptor structure. Calcium cages, acid baths and recycling receptors. Nature, 1997, 388(6643): 629-630.
ZHENG G, CHEN J, LI H, et al. Rerouting lipoprotein nanoparticles to selected alternate receptors for targeted delivery of cancer diagnostic and therapeutic agents. Proc Natl Acad Sci USA, 2005, 102(49): 17757-17762.
VAN B T J C. Drug targeting: Application of endogenous carriers for site specific delivery of drug. J Controlled Release, 1993, 24(1-3): 145-155.
HUNTOSOVA V, BUZOVA D, PETROVAJOVA D, et al. Development of a new LDL-based transport system for hydrophobic/amphiphilic drug delivery to cancer cells. Int J Pharm, 2012, 436(1-2): 463-471.
JOANNA K, IVANA C, PAOLO O, et al. A LDL-masked liposomal-doxorubicin reverses drug resistance in human cancer cells. J Controlled Release, 2011, 149(2): 196-205.
ZHU Q L, ZHOU Y, GUAN M, et al. Low-density lipoprotein-coupled N-succinyl chitosan nanoparticles co-delivering siRNA and doxorubicin for hepatocyte-targeted therapy. Biomaterials, 2014, 35(22):5965-5976.
SUTTON D, NASONGKLA N, BLANCO E, et al. Functionalized micellar systems for cancer targeted drug delivery. Pharm Res, 2007,24(6): 1029-1046.
PDF(1891 KB)

Accesses

Citation

Detail

段落导航
相关文章

/