本文对近些年关于硝基咪唑类药物研究的文献进行查阅、分析和归纳,论述了硝基咪唑类药物的基本特性、抗菌活性、人体内代谢过程及药动/药效学特点。通过系统的综述可知,硝基咪唑类药物与其他药物广泛应用于厌氧菌与需氧菌混合感染,在人体内的代谢过程与肝脏细胞色素P450酶系统相关,而AUC/MIC为评价甲硝唑药动/药效学特性的最优参数。但关于硝基咪唑类药物的具体作用机制以及全面的药动/药效学特点需进一步的探索与研究。

This paper had consulted,analysed,concluded and summarized the studies of nitroimidazoles to expound their basic characteristics, antibacterial activity, metabolic processes and PK/PD characteristics. It could be found by the means of systematic review that nitroimidazoles are widely used in anaerobic and aerobic mixed infections with other drugs, and their metabolic processes in human body areassociated with hepatic cytochrome P450 enzyme system, and AUC/MIC is the optimal parameters for evaluating PK/PD characteristics of metronidazole. But the specific mechanisms and PK/PD characteristicsof nitroimidazoles need further exploration and research.