Abstract��OBJECTIVE To systematically review the effectiveness and safety of pantoprazole in comparison with ranitidine for patients with duodenal ulcer, and evaluate the cost of the two drugs. METHODS PubMed, Medline, EMbase, the Cochrane Library and three Chinese literature databases (VIP, CNKI and WanFang) were searched. Randomized controlled trials(RCTs) that compared the clinical outcomes of pantoprazole (PAN) group vs. ranitidine(RAN) group for duodenal ulcer were included. Two reviewers independently screened literature in accordance with the inclusion and exclusion criteria, extracted the data and assessed the methodological quality of included studies. Then, meta-analysis was performed using RevMan 5.2 software and cost-effectiveness analysis was performed with the decision tree model. RESULTS A total of six RCTs involving 1 225 patients were included. The results of meta-analysis showed that PAN was superior to RAN in the 2-week or 4-week ulcers healing rates . Compared with RAN groups, PAN group had significantly higher rates of pain and gastrointestinal symptoms relief. While there was no significant difference in the incidence of adverse events between the PAN and the RAN groups . And the cost-effectiveness ratio was lower in the RAN group than in the PAN group(29.33 vs 53.90). CONCLUSION Current evidence indicates that, pantoprazole is an effective scheme for duodenal ulcer, and ranitidine is considered as an economic choice. Both treatments are safe and well tolerated.
�ż���,����Ԫ,л��,����,����,����,������,������,ʢ����. ���������������涡����ʮ��ָ�������ϵͳ���ۼ�ҩ�ﾭ��ѧ����[J]. �й�ҩѧ��־, 2015, 50(13): 1160-1164.
ZHANG Jia-xing, WANG Zhong-yuan, XIE Juan, CHEN Qi, GAO Ling, LUO Lei, LI Lian-hua, XIONG Shi-juan, SHENG Chang-cheng. Pantoprazole and Ranitidine in Treatment of Duodenal Ulcer: A Systematic Review and Pharmacoeconomics Analysis. Chinese Pharmaceutical Journal, 2015, 50(13): 1160-1164.
LIU W J. Comparison on the efficacy of the two treatment for the Hp positive duodenal. Chin J Gerontol (�й�����ѧ��־), 2012, 32(10): 2186-2187.
[2]
CMA. Clinical Diagnosis and Treatment Guidelines��Archies of Digestive System Diseases(�ٴ�����ָ�ϡ�������ϵͳ�����ֲ�). Beijing: People��s Medical Publishing House, 2004:32-34.
[3]
CHEN J Y, WANG M X, WANG H M, et al. Study on effect of pantoprazole, omeprazole and famotidine on the treatment of peptic ulcer. Mod Med Health Care(�ִ�ҽҩ����), 2010, 26 (11): 1620-1622.
[4]
ZHANG K B. The efficacy of the pantoprazole quadruple therapy for the Hp positive duodenal. Cent Plains Med J(��ԭҽ��), 2003, 30(16): 7-10.
[5]
HIGGINS J P T, GREEN S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collbration, 2011http://handbook.cochrane.org/.
[6]
TANG S H, HU W. Effect of pantoprazole in the treatment of peptic ulcer. Her Med (ҽҩ����), 2001, 20(7): 431-432.
[7]
CREMER M, LAMBERT R, LAMERS C B H W, et al. A double-blind study of pantoprazole and ranitidine in treatment of acute duodenal ulcer. A multicenter trial. European Pantoprazole Study Group. Digest Dis Sci, 1995, 40(6): 1360-1364.
[8]
SCHEPP W, CLASSEN M. Pantoprazole and ranitidine in the treatment of acute duodenal ulcer. A multicentre study. Scand J Gastroentero, 1995, 30(6): 511-514.
[9]
JUDMAIER G, KOELZ H R. Comparison of pantoprazole and ranitidine in the treatment of acute duodenal ulcer. Aliment Pharm Therap, 1994, 8(1): 81-86. MENEGHELLI U G, ZATERKA S, DE PAULA CASTRO L, et al. Pantoprazole versus ranitidine in the treatment of duodenal ulcer: A multicenter study in Brazil. Am J Gastroenterol, 2000, 95(1): 62-66. VAN R C J, VAN E P J, MARKS I N, et al. Improved duodenal ulcer healing with pantoprazole compared with ranitidine: A multicentre study. Eur J Gastroen Hepat, 1994, 6(8): 739-743. IKEDA S, TAMAMURO T, HAMASHIMA C, et al. Evaluation of the cost-effectiveness of Helicobacter pylori eradication triple therapy vs. conventional therapy for ulcers in Japan. Aliment Pharm Therap, 2001,15(11): 1777-1785. ALAN N B, VICIANE A, MYRIAM M, et al. Cost-effectiveness analysis: Stress ulcer bleeding prophylaxis with proton pump inhibitors, H2 receptor antagonists. Value Health, 2013, 16(1): 14-22. LIU D, SUN M J, WEI M J. System evaluation of the efficacy of pantoprazole in treating duodenal ulcer patients. Chin J Hosp Pharm(�й�ҽԺҩѧ��־), 2012, 32(2): 141-144.
2015, Vol. 50 
