Abstract��
OBJECTIVE To assess systematically the impact of pharmacist-participated anticoagulation service on warfarin therapy management. METHODS Databases of the OVID, SCI, CBM, CNKI, VIP,WANFANG were searched, randomized controlled trials(RCTs)of warfarin anticoagulation management by pharmacists were included (up to January 2014), systematically selected studies, extracted data and evaluated quality,then meta-analysis were carried out using RevMan 5.0 if there was homogeneity.RESULTS Nine RCTs were included, Meta-analysis indicated the differences of the percentage of the time spent within the therapeutic range,the percentage of the time spent within the extended therapeutic range(target INR��0.2),the all-cause mortality,the incidence of the major bleeding complications and the incidence of the thromboembolic complications between groups were no significant:MD=1.24,95%CI(-2.83,5.30),P=0.55,MD=2.86,95%CI(-1.52,7.25),P=0.20,RR=0.87,95%CI(0.40,1.91),P=0.73,RR=0.65,95%CI(0.32,1.34),P=0.24,RR=0.85,95%CI(0.40,1.78),P=0.66,in that order.However,the score of patients�� satisfaction questionnaire indicated the trial group was well received by the patient(P��0.001). CONCLUSION Based on current clinical evidence, besides increasing patients�� satisfaction,the other positive effects of pharmacist-participated anticoagulation service on warfarin therapy management still needs further research.
LUO Min,
WU Bin,
WU Feng-Bo etc
.Impact of Pharmacist-Participated Anticoagulation Service on Warfarin Therapy Management:A Systematic Review[J] Chinese Pharmaceutical Journal, 2015,V50(6): 554-558
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