Abstract��
OBJECTIVE To prepare mannitol and starch co-processed compound for direct compression. METHODS The compound was prepared with granulation technique, and the ratio of mannitolto starch was 20��1. Then the compound was compared to the physical blend to evaluate its properties. RESULTS The compound exhibited good flowability, packing rate, compressibility, and shorter disintegration time. It also improved the content uniformity of low dosage formulations. CONCLUSION The compound is superior to physical blend as drug carrier and suitable for direct compression.
YIN Zong-Mei,
WANG Nuan-Sheng,
JI Wei etc
.Preparation of a Co-Processed Compound Based on Mainnitol and Starch Fordirect Compression and Properties Evaluation[J] Chinese Pharmaceutical Journal, 2015,V50(4): 348-351
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