Abstract��
OBJECTIVE To summarize advances in applying dual-targeting for the treatment of brain diseases.METHODS The related literatures referring to dual-targeting nanocarrier-based delivery system in recent years were summarized.RESULTS The drug carrier was modified with bifunctional-ligands, which could help the drug delivery system penetrate the blood-brain barrier and concentrate on lesions, thus improving the drug efficacy and reducing the side effects. CONCLUSION The dual-targeting system had a promising future in the field of brain disease.
ZHENG Xiao-Yao,
ZHANG Qi-Zhi-*,
JIANG Xin-Guo
.Research Advances in Dual-Targeting Nanocarrier-Based Delivery System for the Treatment of Brain Diseases[J] Chinese Pharmaceutical Journal, 2014,V49(18): 1573-1576
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BRASNJEVIC I, STEINBUSCH H W M, SCHMITZ C,et al. Delivery of peptide and protein drugs over the blood-brain barrier [J]. Prog Neurobiol, 2009, 87(4): 212-251.[2] AARSLAND D, HUTCHINSON M, LARSEN J P. Cognitive, psychiatric and motor response to galantamine in Parkinson's disease with dementia [J]. Int J Geriatr Psychiatry, 2003, 18(10): 937-941.[3] PARDRIDGE W M. Crossing the blood-brain barrier: Are we getting it right[J]. Drug Discov Today, 2001, 6(1): 1-2.[4] JIANG X G. Brain-targeting Drug Delivery System(�����ҩϵͳ)[M]. Beijing:People's Medical Publishing House, 2011:1-20.[5] PARDRIDGE W M. Brain drug development and brain drug targeting [J]. Pharm Res, 2007, 24(9): 1729-1732.[6] CHENG Y, MORSHED R A, AUFFINGER B,et al. Multifunctional nanoparticles for brain tumor imaging and therapy [J]. Adv Drug Deliv Rev, 2014, 66: 42-57.[7] ZHANG P, HU L, YIN Q,et al. Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: Synthesis, preparation and in vivo evaluation[J]. J Controlled Release, 2012, 159(3): 429-434.[8] JI B, MAEDA J, HIGUCHI M,et al. Pharmacokinetics and brain uptake of lactoferrin in rats [J]. Life Sci, 2006, 78(8): 851-855.[9] SUN X, PANG Z, YE H,et al. Co-delivery of pEGFP-hTRAIL and paclitaxel to brain glioma mediated by an angiopep-conjugated liposome [J].Biomaterials, 2012, 33(3): 916-924.[10] GRAU A J, WILLING V, FOGEL W, et al. Assessment of plasma lactoferrin in Parkinson's disease[J]. Mov Disord, 2001, 16(1): 131-134.[11] PANG Z, GAO H, YU Y,et al. Brain delivery and cellular internalization mechanisms for transferrin conjugated biodegradable polymersomes [J]. Int J Pharm, 2011, 415(1-2): 284-292.[12] KUANG Y, AN S, GUO Y,et al. T7 peptide-functionalized nanoparticles utilizing RNA interference for glioma dual targeting [J]. Int J Pharm, 2013, 454(1): 11-20.[13] DEMEULE M, CURRIE J C, BERTRAND Y,et al. Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2 [J]. J Neurochem, 2008, 106(4): 1534-1544.[14] REN J, SHEN S, WANG D,et al. The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2 [J]. Biomaterials, 2012, 33(11): 3324-3333.[15] XIN H, JIANG X, GU J,et al. Angiopep-conjugated poly(ethylene glycol)-co-poly(epsilon-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma [J]. Biomaterials, 2011, 32(18): 4293-4305.[16] ZHANG B, SUN X, MEI H,et al. LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma [J]. Biomaterials, 2013, 34(36): 9171-9182.[17] HUANG R, KE W, QU Y,et al. Characterization of lactoferrin receptor in brain endothelial capillary cells and mouse brain [J]. J Biomed Sci, 2007, 14(1): 121-128.[18] HUANG R, KE W, LIU Y,et al. The use of lactoferrin as a ligand for targeting the polyamidoamine-based gene delivery system to the brain [J]. Biomaterials, 2008, 29(2): 238-246.[19] HUANG R, KE W, HAN L,et al. Brain-targeting mechanisms of lactoferrin-modified DNA-loaded nanoparticles [J]. J Cereb Blood Flow Metab, 2009, 29(12): 1914-1923.[20] HUANG R, HAN L, LI J, et al. Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles[J]. J Gene Med, 2009, 11(9): 754-763.[21] PARDRIDGE W M. Drug and gene targeting to the brain via blood-brain barrier receptor-mediated transport systems[C]. International Congress Series, Copenhagen Elsevier, 2005, 1277(0): 49-62.[22] ZHANG Y, ZHANG Y F, BRYANT J,et al. Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer [J]. Clin Cancer Res, 2004, 10(11): 3667-3677.[23] YING X, WEN H, LU W L,et al. Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals [J]. J Controlled Release, 2010, 141(2): 183-192.[24] GAO J, LV Q, LI L,et al. Glioma targeting and bloodebrain barrier penetration by dual-targeting doxorubincin liposomes [J]. Biomaterials, 2013,34(22):5628-5639.[25] GAO H, QIAN J, CAO S,et al. Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles [J]. Biomaterials, 2012, 33(20): 5115-5123.[26] HUILE G, SHUAIQI P, ZHI Y,et al. A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein [J]. Biomaterials, 2011, 32(33): 8669-8675.[27] ZHANG C, WAN X, ZHENG X,et al. Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice [J]. Biomaterials, 2014, 35(1): 456-465.[28] IVATURI S, WOOTEN C J, NGUYEN M D,et al. Distribution of the LDL receptor within clathrin-coated pits and caveolae in rat and human liver [J]. Biochem Biophys Res Commun, 2014, 445(2): 422-427.[29] ZHENG G, BACHINSKY D R, STAMENKOVIC I,et al. Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP) [J]. J Histochem Cytochem, 1994, 42(4): 531-542.[30] HONG H Y, CHOI J S, KIM Y J,et al. Detection of apoptosis in a rat model of focal cerebral ischemia using a homing peptide selected from in vivo phage display [J]. J Controlled Release, 2008, 131(3): 167-172.[31] YAN H, WANG L, WANG J,et al. Two-order targeted brain tumor imaging by using an optical/paramagnetic nanoprobe across the blood brain barrier [J]. ACS Nano, 2012, 6(1): 410-420.[32] GAO X, LI C. Nanoprobes visualizing gliomas by crossing the blood brain tumor barrier [J]. Small, 2014, 10(3): 426-440.
2014, Vol. 49 
