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�й�ҩѧ��־ 2014, Vol. 49 Issue (7) :578-582    DOI: 10.11669/cpj.2014.07.017
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LI Jin-wei, LIU Zhong-bing, YU Xin, JIANG Xing, JING Pei, XIONG Dan, LIU Yi-long, ZHONG Zhi-rong*
School of Pharmacy, Luzhou Medical College, Luzhou 646000, China

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Abstract�� OBJECTIVE To optimize the formulation of aspirin ointment. METHODS With cumulative permeation quantity within 6 h and shin irritation as indexes, the method of central composite design was used to optimize the formulation of aspirin ointment, taking the most important three ingredients including sodium lauryl sulfate(X1), sodium citrate (X2)and triethanolamine(X3)as the study subjects. RESULTS The optimized formulation of aspirin ointment was composed of 1.41% sodium lauryl sulfate, 3.5% sodium citrate and 3.0% triethanolamine. Three batches of aspirin ointment were prepared using the optimized formulation, for which the average cumulative permeation quantity within 6 h was 990.18 ��g��cm-2, and no obvious shin irritation was observed. CONCLUSION Central composite design is successfully used to optimize the formulation of aspirin ointment.
Keywords�� aspirin ointment,   central composite design,   prescription optimization     
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LI Jin-Wei, LIU Zhong-Bing, YU Xin etc .Application of Central Composite Design in Optimization of the Formulation of Aspirin Ointment[J]  Chinese Pharmaceutical Journal, 2014,V49(7): 578-582
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