Abstract��
OBJECTIVE To optimize the formulation of aspirin ointment. METHODS With cumulative permeation quantity within 6 h and shin irritation as indexes, the method of central composite design was used to optimize the formulation of aspirin ointment, taking the most important three ingredients including sodium lauryl sulfate(X1), sodium citrate (X2)and triethanolamine(X3)as the study subjects. RESULTS The optimized formulation of aspirin ointment was composed of 1.41% sodium lauryl sulfate, 3.5% sodium citrate and 3.0% triethanolamine. Three batches of aspirin ointment were prepared using the optimized formulation, for which the average cumulative permeation quantity within 6 h was 990.18 ��g��cm-2, and no obvious shin irritation was observed. CONCLUSION Central composite design is successfully used to optimize the formulation of aspirin ointment.
LI Jin-Wei,
LIU Zhong-Bing,
YU Xin etc
.Application of Central Composite Design in Optimization of the Formulation of Aspirin Ointment[J] Chinese Pharmaceutical Journal, 2014,V49(7): 578-582
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[1]
ZHANG J P, WANG H Y, LIU H. Study on direct powder compression of aspirin tablet. Chin J New Drugs(�й���ҩ��־), 2003, 12(1):45-46. [2] LEVANG A K, ZHAO K, SINGH J. Effect of ethanol/ propylene glycol on the in vitro percutaneous absorption of aspirin, biophysical changes and macroscopic barrier properties of the skin. Int J Pharm,1999, 181(2):255-263. [3] AAMMAR H O, GHORAB M, El-NAHHAS S A, et al. Design of a transdermal delivery system for aspirin as an antithrombotic drug. Int J Pharm, 2006, 327(1-2):81-88. [4] AMMAR H O, GHORAB M, El-NAHHAS S A, et al. Evaluation of chemical penetration enhancers for transdermal delivery of aspirin. Asian J Pharm Sci, 2007, 2(3):96-105.[5] SHAMSHER A A, CHARNOO N A, KOHLI K, et al. Effect of transdermally delivered aspirin on blood coagulation parameters. Am J Biomed Sci, 2010, 2(2):129-141. [6] SHENG H L, TU J S. Application of spherical symmetric design in pharmaceutics. J China Pharm Univ(�й�ҩ�ƴ�ѧѧ��), 1996, 27(4):211- 214. [7] LIN S Q, HONG J H, LI F, et al. Preparation of compound aspirin ointment and effect of citriodora oil on transdermal enhancing action of aspirin. China Pharm(�й�ҩҵ), 2011, 20(10):25-27. [8] LI L H, YANG M H, SUN Z J. Shuanghuanglian solution agent anti-inflammatory effects and skin irritation test. China Pharm(�й�ҩʦ), 2010, 13(8):1131-1133. [9] GUO H. Design and evaluation of oxaprozin transdermal delivery system. Shenyang:Shenyang Pharmaceutical University, 2007. [10] ARAUJO P W, BRERETON R G. Experimental design ��:optimization. Trends Anal Chem, 1996, 15:63-70. [11] LI J, PING Q N, FAN R. Studies on preparation of fenoprofen calcium gels and its percutaneous absorption in vitro. Chin J Hosp Pharm(�й�ҽԺҩѧ��־), 1999, 19(6):323-325.
2014, Vol. 49 