FU Yan-hui1, 2, ZHONG Jun2*, LUO Su-qin1*, HOU Qing-wei2, WANG Guo-cheng2, ZHAN Ming-zhe3
1.College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China; 2.Chemical Medicine Department of Tasly R&D Institute, Tasly Holding Group Co., Ltd.,Tianjin 300410, China; 3.The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China
Abstract��
OBJECTIVE To introduce the research progress in total-and semi-synthesis of artemisinin. METHODS The review was based on representative literatures, and the data was summarized and analyzed. RESULTS AND CONCLUSION Artemisinin is one of the most effective anti-malarial medicines. Since its discovery, artemisinin chemical synthesis has become a hot research topic. Nine total-synthesis methods and five semi-synthesis methods were summarized, for which the overall yields were up to 10% and 60% respectively. Efficient synthesis of artemisinin in large scale by industry would be realized in the near future, and it will benefit hundred millions of patients.
FU Yan-Hui-,
,
ZHONG Jun-* etc
.Progress in the Chemical Synthesis of Artemisinin[J] Chinese Pharmaceutical Journal, 2014,V49(10): 795-805
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2014, Vol. 49 
