目的 研究硫酸头孢噻利在小鼠脑内药动学特征。方法 小鼠单次尾静脉注射头孢噻利后, 不同时间点取小鼠脑组织并以HPLC测定脑内药物含量, 采用DAS3.1软件处理, 计算药动学参数并进行统计学分析。结果 小鼠脑中硫酸头孢噻利的主要药动学参数t1/2为 0.261 h, cmax18.728 μg·g-1, AUC0-t10.119 μg·h·g-1, MRT0-t1.945 h。结论 小鼠单次尾静脉注射硫酸头孢噻利后, 在脑内分布快, 呈一室模型, 提示硫酸头孢噻利外周静脉给药能有效的治疗细菌引起的颅内感染。
Abstract
OBJECTIVE To study pharmacokinetic profile of cefoselis sulfate in mice brain.METHODS Brain samples were collected at different time points after caudal vein administration of cefoselis sulfate at single bolus dose, HPLCMETHODS were validated to analysis drug concertations, and pharmacokinetic parameters were calculated by professional software named DAS3.1 pharmacokinetic program.RESULTS The main pharmacokinetic parameters of cefoselis sulfate in mice brain was about: t1/20.261 h, cmax 18.728 μg·g-1, AUC0-t 10.119 μg·h·g-1, and MRT0-t 1.945 h. CONCLUSION The distribution of cefoselis sulfate is extremely fast in mice brain after administration, appeared to best fit the kinetics of a one-compartment model, the RESULTS indicate that cefoselis sulfate viaperipheralintravenous admininstraion is efficacy to theraphy the intracranial infection.
关键词
硫酸头孢噻利 /
脑组织 /
药动学
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Key words
cefoselis sulfate /
brain /
pharmacokinetics
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中图分类号：
R285
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参考文献
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脚注
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基金
浙江省医学会临床科研基金项目(2011ZYC-A120)
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