1. The Affiliated Hospital of Shanxi Traditional Chinese Medicine College ShanXi Xianyang 712000;
2. The First Affiliated Hospital of Guangxi Traditional Chinese Medicine College GuangXi Nanning 530023
Abstract��
To explore the effect of Aitongxiao granule(traditional Chinese medicines) therapy on miRNAs of replant liver cancer rats. METHODS The 60 replant liver cancer rats were randomly divided into high dose(A), middle dose(B), lower dose(C), 5-Fu(D),distilled water(E)groups. After 14 days of experimental treatment, the expressions of miR-199a-3p��miR-199a-5p ��miR-18 in liver cancer tissues were detected with qRT-PCR. RESULTS Before experimental treatment,in comparison with E group, the level of miR-18 was higher but level of miR-199a-3p, miR-199a-5p were lower in A��B��C��D groups(P<0.01). After 14 days of experimental treatment, in comparison with E group, the level of miR-18 was lower but level of miR-199a-3p, miR-199a-5p were higher in A��B��C��D groups(P<0.01).The more significant differences were found in B group than that in D group. CONCLUSION The Aitongxiao granule has the regulative effects on miRNAs of replant liver cancer rats . Its therapeutical effects relate to the miRNAs expressions of liver cellular cancer development .
HUANG Feng-,
WEI Ai-Ling-*
.The Effect on miRNAs of Replant Liver Cancer Rats Treated by Aitongxiao Granule[J] Chinese Pharmaceutical Journal, 2013,V48(20): 1740-1743
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[1]
WEI L C,WEI A L. The experimental study on the expression of MVD VEGF of hepatoma in rats with the Aitongxiao granule. J Liaoning Univ Tradit Chin Med(������ҽҩ��ѧѧ��),2008,10(8):159-160. SHIMADA K,SAKAMOTO Y,ESAKI M,et al. Analysis of prognostic factors affecting survival after initial recurrence and treatment efficacy for recurrence in patients undergoing potentially curative hepatectomy for hepatocellular carcinoma.Ann Surg Oncol,2007,14(8):2337-2347. MURADAMI Y,YASUDA T, SAIGO K, et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues.Oncogene,2006, 25: 2537-2545. WEI A L,TANG J .The efficacy analysis of the liver blood stasis toxin knot and deficiency in primary hepatic carcinoma with Aitongxiao granule. J Liaoning Univ Tradit Chin Med(������ҽҩ��ѧѧ��), 2007, 34(5):570-572. WEI L C, WEI A L. The study on the rat hepatoma cell apoptosis and Bcl-2 expression with Aitongxiao granule. J Jiangxi Univ Tradit Chin Med(������ҽҩ��ѧѧ��),2008,20(3):82-84.
2013, Vol. 48 
