Abstract��
To study the anti-inflammatory and analgesic effects of vitacoxib. METHODS The in vitro COX-1 and COX-2 inhibitory activities of vitacoxib were tested in human whole blood assay as well as canine whole blood assay. The anti-inflammatory and analgesic effects of vitacoxib were evaluated in several in vivo models including croton oil induced mouse ear endema, carrageenan-induced rat paw swelling and mouse acetic acid writhing model. RESULTS In vitro assay, vitacoxib has potent inhibitory COX-2 activity and selectivity for COX-2 over COX-1. In vivo anti-inflammatory experiments, vitacoxib has significant inhibitory activities both in croton oil-induced mouse ear oedema model test(P<0.01)and the carrageenan-induced rat paw swelling test(P<0.05). In vivo analgesic effect experiments, vitacoxib has significant inhibitory activity on acetic acid-induced writhing pain in mice(P<0.05).CONCLUSION Vitacoxib, a selective COX-2 inhibitor, demonstrates excellent anti-inflammatory activity in both in vitro and in vivo models tested.
CAO Yan-Hua-,
LI Jing-,
��Peng-Yue- etc
.The Anti-Inflammatory and the Analgesic Effects of Vitacoxib, a New Molecular Entity[J] Chinese Pharmaceutical Journal, 2013,V48(20): 1736-1739
��
[1]
THANA TURAJANE M D, RUNGSEE WONGBUNNAK M D,TANISA PATCHARATRAKUL M D, et al. Gastrointestinal and Cardiovascular Risk of Non-selective NSAIDs and COX-2 Inhibitors in Elderly Patients with 3 Knee Osteoarthritis. J Med Assoc Thai. 2009,92:19-26. HARRIS RE, BEEBE-DONK J, DOSS H, et al. Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: A critical review of non-selective COX-2 blockade(review). Oncol Rep, 2005,13(4):559-583. PATRIGNANI P, PANARA M R, SCIULLI M G, et al. Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs . J Physiol Pharmacol, 1997, 48: 623-631. WARNER T D, GIULIANO F, VOJNOVIC I, et al. Nonsteroid drugs selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis . Proc Natl Acad Sci USA, 1999, 96: 7563~7568. XU S Y, BIAN R L, CHEN X. Experimental Methodology of Pharmacology (ҩ��ʵ�鷽��ѧ). 3rd ed.Beijing: The People��s Medical Publishing House, 2001: 877-928.
2013, Vol. 48 