1. Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,Jiangsu Provincial Academy of Chinese Medicine,Jiangsu Province,Nanjing 210028,China; 2. Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing 210046,China
Abstract��
OBJECTIVE To prepare hydrophobic nano-CaCO3 by nano-CaCO3 and stearic acid. And to prepare tripterine solid dispersion using the new material as a carrier by solvent method. METHODS The structure of modified nano-CaCO3 was characterized by TEM,DSC,XRD and FTIR. Meanwhile the solid dispersions were characterized by SEM,DSC,XRD and FTIR,and the in vitro dissolution test of tripterine was performed. RESULTS When the ratio of drug to modified nano-CaCO3 was 1��4,tripterine could be dispersed amorphously in the carrier. And the accumulative drug-release percentage in vitro at 0.5 h was 7.05%. With the time increasing,the accumulative drug-release percentage also increased to 90.03% at 12 h. Moreover,tripterine solid dispersion had a better sustained release effect.CONCLUSION The nano-CaCO3 modified by stearic acid can be used as controlled-release carrier for tripterine.
CHEN Xiao-Yun-,
,
ZHANG Zhen-Hai- etc
.Sustained Release Solid Dispersion of Tripterine Carried by Modified Nano-CaCO3[J] Chinese Pharmaceutical Journal, 2013,V48(16): 1380-1384
��
[1]
RAO S,NAGABHUSHANAM M V,CHOWDARY K P R.In vitro dissolution studies on solid dispersions of mefenamic acid.Indian J Pharm Sci,2011,73(2):243-247.[2] ZHANG Y,DU Z,LI C M,et al.Preparation of tanshinone��A solid dispersion by spray freeze drying and Its characterization.Chin Pharm J (�й�ҩѧ��־),2012,47 (3):204-208.[3] WAN S X,SUN Y Q,QI X X,et al.Improved bioavailability of poorly water-soluble drug curcumin in cellulose acetate solid dispersion.AAPS Pharm Sci Tech,2012,13(1) :159-166.[4] RAMANA G,JYOTHFTIRMAI D,SRI VAISHNAVI P.Sustained release of nifedipine from matrix tablets of its solid dispersions employing superdisintegrants.Int Res J Pharm,2011,2(9) :166-169.[5] HUANG J J,LI Y,WIGENT R J,et al.Interplay of formulation and process methodology on the extent of nifedipine molecular dispersion in polymers.Int J Pharm,2011,420(1):59-67.[6] BASKARAN R,SAROJADEVI M,VIJAYAKUMAR C T.Mechanical and thermal properties of unsaturated polyester/calcium carbonate nanocomposites.J Rein Plast Compos,2011,30(18) :1549-1556.[7] KAMAL M,SHARMA C S,UPADHYAYA P,et al.Calcium carbonate (CaCO3 ) nanoparticle filled polypropylene: Effect of particle surface treatment on mechanical,thermal,and morphological performance of composites .J Appl Polym Sci,2012,124(4) :2649-2656.[8] LI L,ZHU Y J,CAO S W,et al.Interplay of formulation and process methodology on the extent of nifedipine molecular dispersion in polymers.J Inorg Mater,2009,24(1):166.[9] GU J,XIONG Q,JIA D M,et al.Effect of unsaturated hydroxyl-fatty acid modified nano-CaCO3 on the morphological and rheological behavior of PP.Front Chem China,2009,4(1):75-82. ZHANG H,ZENG X F,GAO Y F,et al.A facile method to prepare superhydrophobic coatings by calcium carbonate.Ind Eng Chem Res,2011,50(6):3089-3094. SONAWANE S H,KAPADNIS C V.Sonochemical formation of CaCO3 nanoparticles with controlled particle size distribution .Int J Green Nanotechnol,2010,2(2):69-79. LIU W P,LIU S X,BAI M,et al.New advances in the study of Tripterygium wilfordii.Chin Tradit Herb Drugs(�в�ҩ),2010,41:1215. YANG T J,YAN X.Research progress in surface modification technology of nanometer calcium carbonate.Inorganic Chem Ind(���ι�ҵ),2012,44(2):9-12. MA X K,LIU Y H,YU Y,et al.The influence of the different modifying agents on the synthesis of poly(methylmethacrylate)-calcium carbonate nanocomposites via soapless emulsion polymerization.J Appl Polym Sci,2008,108(3):1421-1425. SONG J,LI Y M,TANG Y J.Study on surface modification of CaCO3 nano-particles via wet route in water phase.China Powder Sci Technol(�й����弼��),2007,14:12-15. GU J,JIA D S,CHENG R S.Polypropylene composite toughened by a novel modified nano-CaCO3.Polym Plast Technol Eng,2008,47(6) :583-589. ZHAO L N,ZHAO X,REN S X,et al.In situ synthesis and surface modification of calcium carbonate .Acta Phys Chim Sin(����ѧѧ��),2009,25(1):47-52. LI Y H,HU F Q,YUAN H.Preparation and release profiles of chitosan oligosaccharide grafted stearic acid nanoparticles in vitro in vitro.Chin Pharm J (�й�ҩѧ��־),2005,40(14):1083-1086. WANG Y F,LI B X,XU C Y.Fabrication of superhydrophobic surface of hierarchical ZnO thin films by using stearic acid.Superlattices Microstruct,2012,51(1):128-134.
2013, Vol. 48 
