SUN Min-jie1,YOU Wei-liang1,ZHANG Jie1,CAO Wei3, SHI Hua-ping2*
1��Department of Pharmacy,School of Pharmaceutics,China Pharmaceutical University,Nanjing 211198,China; 2 Pre Clinical Medicine College ,Nanjing University of Chinese Medicine,Nanjing 210046,China; 3 Jiangsu Patent Examination Assistance Center Under SIPO,Suzhou 215011,China
Abstract��
Objective To prepare an o/w type geniposide cream and to investigate its stability. METHODS Appropriate base was selected by uniform design�� suitable preservative and penetration enhancer were chosen according the characteristics of the cream. Franz diffusion cell was used to evaluate the transdermal characteristics in vitro�� the stability and rheology of the cream were evaluated. RESULTS The optimum matrix was composed of oil phase of volume faction 33%,emulsifying agent 6%,and preservative 0.3%. The content of geniposide was 0.5%. The emulsifying temperature was 80 ��. The cream was uniform in color,homogeneous,exquisite and easy to spread�� 12 h cumulative penetration amount was ��212.73±22.76��μg·cm-2. The contents and pHs of three batches of samples were in accordance with the quality standard after storage at 40 ��,25 �� and 4 �� for 3 months. CONCLUSION Geniposide cream is very stable and has good transdermal characteristics in vitro,which is a new dosage form for transdermal drug delivery.
SUN Min-Jie-,
YOU Wei-Liang-,
ZHANG Jie- etc
.Preparation and Stability of geniposide Cream[J] Chinese Pharmaceutical Journal, 2013,V48(6): 455-460
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2013, Vol. 48 
