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�й�ҩѧ��־ 2013, Vol. 48 Issue (6) :455-460    DOI: 10.11669/cpj.2013.06.014
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1.�й�ҩ�ƴ�ѧҩѧԺҩ��������,�Ͼ���211198; 2.�Ͼ���ҽҩ��ѧ����ҽѧԺ,�Ͼ� 210046; 3.����֪ʶ��Ȩ��ר����ר�����Э����������, ���� ���� 215011
SUN Min-jie1,YOU Wei-liang1,ZHANG Jie1,CAO Wei3, SHI Hua-ping2*
1��Department of Pharmacy,School of Pharmaceutics,China Pharmaceutical University,Nanjing 211198,China; 2 Pre Clinical Medicine College ,Nanjing University of Chinese Medicine,Nanjing 210046,China; 3 Jiangsu Patent Examination Assistance Center Under SIPO,Suzhou 215011,China

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ժҪ Ŀ�� �Ʊ�����ƽ����ಢ�����ȶ��ԡ����� ��������������Ʒ�ɸѡ���˻���,ɸѡ�˲�ͬ�Ĵ��������������Ƴ�o/w�͵����,����Franz ��ɢ�ض������������͸Ƥ���Խ����˿���,Ȼ�����������ѧ���ȶ��Խ��п��졣��� ���մ�������������������ռ33%���黯������Ϊ6%������������Ϊ0.3%������ƽ��ռ0.5%,�黯�¶�Ϊ80 �档�������Ʊ������ɫ����ȡ��ʵ�ϸ�塢��͸�����á�����Ϳ��; 12 h�ۻ���͸��Ϊ��212.73±22.76��μg·cm-2��ҩƷ�ڳ���(25 ��)����������6����,���£�40 �棩�͵��£�4 �棩����3����,����ƽ�պ������Ƽ�pHֵ�����Ϲ涨������ ����ƽ�������͸������,�����ȶ��ɿ�,������Ϊ����ƽ�վ�Ƥ��ҩ�¼��͡�
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Abstract�� Objective To prepare an o/w type geniposide cream and to investigate its stability. METHODS Appropriate base was selected by uniform design�� suitable preservative and penetration enhancer were chosen according the characteristics of the cream. Franz diffusion cell was used to evaluate the transdermal characteristics in vitro�� the stability and rheology of the cream were evaluated. RESULTS The optimum matrix was composed of oil phase of volume faction 33%,emulsifying agent 6%,and preservative 0.3%. The content of geniposide was 0.5%. The emulsifying temperature was 80 ��. The cream was uniform in color,homogeneous,exquisite and easy to spread�� 12 h cumulative penetration amount was ��212.73±22.76��μg·cm-2. The contents and pHs of three batches of samples were in accordance with the quality standard after storage at 40 ��,25 �� and 4 �� for 3 months. CONCLUSION Geniposide cream is very stable and has good transdermal characteristics in vitro,which is a new dosage form for transdermal drug delivery.
Keywords�� geniposide ,   cream ,   preparation technology ,   stability     
�ո�����: 2012-05-21;
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ͨѶ���� ʩ��ƽ,��,��ʿ �о�������ҩ���ʻ����������о� Tel����025��85811057 E-mail��hpshi@njutcm.edu.cn����ƽ�������Ʊ����ȶ��Կ��� ������1     Email: hpshi@njutcm.edu.cn
���߼��: ������,Ů,��ʿ �о�����ҩ���¼���������ҩϵͳ ͨѶ���ߣ�ʩ��ƽ,��,��ʿ �о�������ҩ���ʻ����������о� Tel����025��85811057 E-mail��hpshi@njutcm.edu.cn
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������, ��ΰ��, �Ž��� .����ƽ�������Ʊ����ȶ��Կ���[J]  �й�ҩѧ��־, 2013,V48(6): 455-460
SUN Min-Jie-, YOU Wei-Liang-, ZHANG Jie- etc .Preparation and Stability of geniposide Cream[J]  Chinese Pharmaceutical Journal, 2013,V48(6): 455-460
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[6] MELINDA G C,LIU P C,JAMES N,et al. Enhanced transdermal delivery of estradiol in vitro using binary vehicles of isopropyl myristate and short-chain alkanols. Int J Pharm,1995,114(2):237-245.
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