1 Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310016,China; 2 College of Pharmaceutical Science,Zhejiang University,Hangzhou 310058,China
Abstract��
Objective To develop hot melt pressure sensitive adhesive (HMPSA) for transdermal use,and to investigate the in vitro drug release and permeation property of HMPSA based patches. METHODS HMPSA was prepared using styrene-isoprene-styrene triblock copolymer (SIS),C5 petroleum resin hydrogenate,lanoline,liquid paraffin,dibutyl phthalate,2,6-ditertbutyl-cresol as material under orthogonal design. The formulation of HMPSA was screened using stickiness,melt temperature and vapor permeation rate as index. The in vitro drug release behavior and transdermal property of the optimized HMPSA were evaluated using α-asarone as model drug. RESULTS The optimized formulation of HMPSA (HMPSA-OP) was followed as: SIS: C5 petroleum resin hydrogenate: lanoline: liquid paraffin: dibutylphthalate: 2,6-ditertbutyl-cresol=100:140:20:40:20:2. HMPSA-OP had shown more rapid drug release than ordinary HMPSA. And the in vitro transdermal flux of HMPSA-OP was ��4.75±0.84��μg·cm-2·h-1,higher than that of ordinary HMPSA and acrylate PSA. CONCLUSION The HMPSA-OP shows good property and was suitable to prepare transdermal patch.
YU Zhen-Wei-,
LIANG Yi-,
LIANG Wen-Quan-*
.Development of Hot Melt Pressure Sensitive Adhesive For Transdermal Use and in Vitro Evaluation[J] Chinese Pharmaceutical Journal, 2013,V48(6): 450-454
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