YANG Ya-nan,FENG Zi-ming,JIANG Jian-shuang,ZHANG Pei-cheng*
State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China
Abstract��
Objective To study the chemical constituents of the roots of Rhodiola crenulata. METHODS The roots of R. crenulata were extracted with 80% ethanol,and the extract was partitioned with ethyl acetate. The chemical components were isolated by various chromatographic methods. Their structures were elucidated by spectral analysis. RESULTS Eleven compounds were isolated and identified as isolariciresinol-9,9′-acetonide(1),p-coumaric acid(2),p-coumaric acid-4-O-β-D-glucopyranoside(3),tachioside(4),dihydroconiferin(5),2-phenylethyl β-glucopyranoside(6),2-phenylethyl β-vicianoside(7),2-phenylethyl-6-O-α-L-arabinofuranosyl-β-D-glucopyranoside(8),2-phenylethyl β-primeveroside(9),benzyl β-D-glucopyranoside(10),and rhodiocyanoside D(11). CONCLUSION All of the compounds were isolated from Rhodiola crenulata for the first time,and compounds 1,3,4,5,7,9 were obtained from the genus of Rhodiola for the first time.
YANG Ya-Nan,
FENG Zi-Ming,
JIANG Jian-Shuang etc
.Chemical Constituents of Roots Rhodiola crenulata[J] Chinese Pharmaceutical Journal, 2013,V48(6): 410-413
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[1]
MAIMESKULOVA L A,MASLOV L N. The anti-arrhythmia effect of Rhodiola rosea and its possible mechanism . Biull Eksp Biol Med,1993,116(8):175-176.
[2]
DEMENTEVA L A,IAREMENKO K V. Effect of a Rhodiola extract on the tumor process in an experiment . Vopr Onkol,1987,33(7):57-60.
[3]
KWON Y I,JANG H D,SHETTY K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension . Asia Pac J Clin Nutr,2006,15(3):425-432.
[4]
YANG Y N,LIU Z Z,FENG Z M,et al. Lignans from the root of Rhodiola crenulata . J Agric Food Chem,2012,60(4):964-972.
[5]
NAKAMURA S,LI X Z,MATSUDA H,et al. Bioactive constituents from Chinese natural medicines. XXVI. Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis . Chem Pharm Bull,2007,55(10):1505-1511.
[6]
KASNOV E A. Flavonoids of Rhodiola litvinovii . Khim Prir Soedin,1979,(6):851-852.
[7]
KAZUKI Y,HIROSHI K,SHIGENOBU A. Non-basic components of Coptisrhizoma. II. Four new hemiterpenoid glucosides,two new phenylpropanoid glucosides and a new flavonoid glycoside from Coptis japonica var. dissecta. . Nat Med(Tokyo),1997,51(3):244-248.
[8]
AUSTIN D J,MEYERS M B. Formation of 7-oxygenated coumarins in hydrangea and lavender . Phytochemistry,1965,4(2):245-254.
HIGUCHI R,ARITOMI M,DONNELLY D M X. Monolignol and dilignol glycosides from Pinus contorta leaves . Phytochemistry,1977,16(7):1007-1011.
[11]
KATSUMI K,MIKIO F,YOSHITERU I,et al. Simple synthesis of β-D-glycopyranosides using β-glycosidase from almonds. Chem Pharm Bull,2004,52(2):270-275.
[12]
MATSUMURA S,TAKAHASHI S,NISHIKITANI M,et al. The role of diglycosides as tea aroma precursors: Synthesis of tea diglycosides and specificity of glycosidases in tea leaves. J Agric Food Chem,1997,45(7):2674-2678.
[13]
WATANABE S,HASHIMOTO I,HAYASHI K,et al. Isolation and identification of 2-phenylethyl disaccharide glycosides and mono glycosides from rose flowers,and their potential role in scent formation . Biosci Biotechnol Biochem,2001,65(2):442-445.
[14]
ZSUZANNA M,VINH T,CHARLES T,et al. Engineering of glucoside acceptors for the regioselective synthesis of β-(1→3)-disaccharides with glycosynthases . Carb Res,2008,343��17��:2939-2946.
[15]
YOSHIKAWA M,SHIMADA H,HORIKAWA S,et al. Constituents of Chinese natural medicines. IV. 1) Rhodiolae Radix.(2). :On the histamine release inhibitors from the underground part of Rhodiola sacra (PRAIN ex HAMET) S. H. Fu(Crassulaceae): chemical structures of rhodiocyanoside D and Sacranosides A and B . Chem Pharm Bull,1996,45(9):1498-1503.