Abstract��
OBJECTIVE To develop immediate-released itraconazole-loaded pellets prepared by fluidized bed spray coating. METHODS With common hydrophilic excipients(HPMC E5�� PVP K30�� PEG6000�� and Poloxamer 188)as the carrier material�� solid dispersion solution(dichloromethane-ethanol�� 1��1�� V/V)containing water-insoluble itraconazole was prepared�� and then was sprayed on the surface of the sugar cores in fluidized bed to directly form immediate-reaease drug-loaded pellets containing itraconazole solid dispersion. Subsequently�� its drug dissolution�� crystal characterization�� appearance�� and residual solvent were evaluated. RESULTS The obtained pellets are clean and beautiful appearance. And itraconazole in the drug-loaded layer exists in amorphous or molecular state�� meets with the solid dispersion structure. It was interesting that�� the pellets containing HPMC E5/itraconazole(1.5��1�� w/w)solid dispersion were of rapid drug dissolution(15 min up to 80%). To ensure that residual solvent within the limits�� it was necessary that the obtained pellets were dried more than 6 h at 80 �� in vacuum. CONCLUSION It is feasible that immediate-release itraconazole-loaded pellets are prepared by fluidized bed spray coating technology�� and its quality could be controlled.
DAN Li,
SHI Yan,
WANG Yu-Li etc
.Formulation and Characterization of Immediate-Release Itraconazole-Loaded Pellets Prepared by Fluidized Bed Spray Coating[J] Chinese Pharmaceutical Journal, 2013,V48(1): 54-58
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[1]
VASCONCELOS T�� SARMENTO B�� COSTA P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs . Drug Discov Today�� 2007�� 12(23-24)��1068-1075.
[2]
SHAN L�� WANG Y L�� YANG M Y�� et al. Granulating process of morindea mfficinalis oligosaccharides capsule based on top spray technique by fluidized bed coater. J Int Pharm Res(����ҩѧ�о���־)�� 2009�� 26(2)�� 81-85.
[3]
JUNG H�� KIM H M�� CHOY Y B�� et al. Laponite-based nanohybrid for enhanced solubility and controlled release of itraconazole.Int J Pharm�� 2008�� 349(1)�� 283-290.
[4]
JANSSENS S�� ARMAS H N D�� ROBERTS C J. Characterization of ternary solid dispersions of itraconazole�� PEG 6000 and HPMC 2910 E5 . J Pharm Sci�� 2008�� 97(6)�� 2110-2120.
[5]
JUNG J Y�� YOO S D�� LEE S H�� et al. Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique . Int J Pharm�� 1999�� 187(2)�� 209-218.
2013, Vol. 48 
