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�й�ҩѧ��־ 2013, Vol. 48 Issue (1) :35-38    DOI:
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�踴���Դ�����ȱѪ���������𶯵��ף�NoGo-A������Ӱ��
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ZHANG Ping��ZHENG Qiao-yun��LI Guo-hui

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Abstract�� OBJECTIVE To study the effect of Chinese herb Suifukang on the expression of Nogo protein-A in the brain of MCAO rats and explore the action mechanism of its promoting neurogenesis. METHODS SD rats were selected and randomized into six groups�� normal group�� control group�� treatment group of methylprednisolone�� treatment group of Chinese herb Suifukang in large-does�� middle-does and small-does. The models of MCAO rats were successfully established by the method of Koizumi. After the surgery�� the rats of drug group had been taken orally Suifukang by 10 g��kg-1 crude drug one time daily�� and the rest groups had been taken orally equivalence saline once a day. The brain of rats were investigated and the expression of NoGo-A was detected by immunohistology method and RT-PCR method. RESULTS The expression of NoGo-A in the injured brain was apparently inhibited by Suifukang(P<0.01). CONCLUSION Suifukang can inhibit the expression of NoGo-A. So this function may be one of the mechanisms that Suifukang can promote the functional recovery after brain injury.
Keywords�� Suifukang,   brain injury,   NoGo-A,   immunohistology     
�ո�����: 2012-05-31;
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ͨѶ���� ����ԣ�Ů������ҩʦ �о�������ҩҩ��ѧ Tel��(010)84739055 E-mail��pinglele@sina.com�踴���Դ�����ȱѪ���������𶯵��ף�NoGo-A������Ӱ��

��ƽ     Email: pinglele@sina.com
���߼��: ��ƽ��Ů��������ҽʦ �о�������ҩ��ѧ ͨѶ���ߣ�����ԣ�Ů������ҩʦ �о�������ҩҩ��ѧ Tel��(010)84739055 E-mail��pinglele@sina.com
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��ƽ, ֣����, ����� .�踴���Դ�����ȱѪ���������𶯵��ף�NoGo-A������Ӱ��[J]  �й�ҩѧ��־, 2013,V48(1): 35-38
ZHANG Ping, ZHENG Qiao-Yun, LI Guo-Hui .Effect of Chinese Herb Suifukang on Expression of NoGo-A Protein in the Brain of MACO Rat[J]  Chinese Pharmaceutical Journal, 2013,V48(1): 35-38
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