Abstract��
OBJECTIVE To study the effect of Chinese herb Suifukang on the expression of Nogo protein-A in the brain of MCAO rats and explore the action mechanism of its promoting neurogenesis. METHODS SD rats were selected and randomized into six groups�� normal group�� control group�� treatment group of methylprednisolone�� treatment group of Chinese herb Suifukang in large-does�� middle-does and small-does. The models of MCAO rats were successfully established by the method of Koizumi. After the surgery�� the rats of drug group had been taken orally Suifukang by 10 g��kg-1 crude drug one time daily�� and the rest groups had been taken orally equivalence saline once a day. The brain of rats were investigated and the expression of NoGo-A was detected by immunohistology method and RT-PCR method. RESULTS The expression of NoGo-A in the injured brain was apparently inhibited by Suifukang(P<0.01). CONCLUSION Suifukang can inhibit the expression of NoGo-A. So this function may be one of the mechanisms that Suifukang can promote the functional recovery after brain injury.
ZHANG Ping,
ZHENG Qiao-Yun,
LI Guo-Hui
.Effect of Chinese Herb Suifukang on Expression of NoGo-A Protein in the Brain of MACO Rat[J] Chinese Pharmaceutical Journal, 2013,V48(1): 35-38
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2013, Vol. 48 
