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�й�ҩѧ��־ 2013, Vol. 48 Issue (1) :17-21    DOI:
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ֲ���������Fusariums sp.LC-1�μ���л������о�
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HU Xiao-lan��XU Wen-feng��LU Xuan��WU Xin��BAI Jiao��PEI Yue-hu

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ժҪ Ŀ�� �о�ֲ���������Fusariums sp.LC-1����Һ������������ȡ��;�˿��ı�ͪ��ȡ���еĻ�ѧ�ɷ֣����ڵõ��л��Ե��ȵ���������� ���ù轺��ɫ�ס�������ɫ�ס���ЧҺ��ɫ�׵ȷ������з��봿����ͨ�������ʺͲ������ݷ�������������Ľṹ����� ��ֲ���������Fusariums sp.LC-1����Һ������������ȡ��;�˿��ı�ͪ��ȡ���й�����õ�17��������ֱ����Ϊ����(��-��)���ģ�1������(��-����)���ģ�2�����׽����أ�3��������޴���4����3β��5α��6β��9α-tetrahydroxyergosta-7��22-diene��5����fusaric acid��6����dehydrofusaric acid��7�������ǻ������ᣨ8������(�Ǹ�-��)���ģ�9������(��-��)���ģ�10������(��-����)���ģ�11������(��-��)���ģ�12������(��-��)���ģ�13������(����-��)���ģ�14������(��-��)���ģ�15��������ण�16����������ण�17�������� ���У�������1��2Ϊ�״δ���Ȼ�����з���õ���������5��9��12��13��14Ϊ�״δ����������з���õ���
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�ؼ����� ֲ���������   �μ���л����   Fusariums sp. LC-1   ��(��-��)����   ��(��-����)����     
Abstract�� OBJECTIVE To study the chemical constituents of the endophyte fungus Fusariums sp.LC-1. METHODS The compounds were isolated from the ethyl acetate extract and acetone extract by silica gel column chromatography��Sephadex LH-20 column chromatography and HPLC techniques. And their structures were identified by the physicochemical properties and spectral analysis. RESULTS Seventeen compounds were obtained from the static liquid culture of endophyte fungus Fusariums sp. LC-1. They were identified as cyclo(Gly-Val)(1)��cyclo(Gly-Ile)(2)��beauvericin(3)��ergosterol(4)��3β��5α��6β��9α-tetrahydroxyergosta-7��22-diene(5)��fusaric acid(6)��dehydrofusaric acid(7)��p-hydroxybenzoic acid(8)��cyclo(Hyp-Leu)(9)��cyclo(Gly- Pro)(10)��cyclo(Ala-Phe)(11)��cyclo(Leu-Ala)(12)��cyclo(Leu-Val)(13)��cyclo(Phe-Gly)(14)��cyclo-(Leu-Gly)(15)��uracil(16)and thymine(17). CONCLUSION Compounds 1 and 2 are isolated from natural material for the first time. Compounds 5��9��12��13 and 14 are isolated from endophyte fungus Fusariums sp. for the first time.
Keywords�� endophyte fungus,   secondary metabolites,   Fusariums sp. LC-1,   cyclo(Gly-Val),   cyclo(Gly-Ile)     
�ո�����: 2012-04-13;
ͨѶ���� ��𨣬Ů�������ڣ�˶ʿ����ʦ �о�������Ȼҩ�� Tel��(024)23986465 E-mail��baijiao@syphu.edu.cnֲ���������Fusariums sp.LC-1�μ���л������о�

������1a     Email: baijiao@syphu.edu.cn
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������, ���ķ�, ¬���� .ֲ���������Fusariums sp.LC-1�μ���л������о�[J]  �й�ҩѧ��־, 2013,V48(1): 17-21
HU Xiao-Lan, XU Wen-Feng, LU Xuan etc .Secondary Metabolites from Endophyte Fungus Fusariums sp.LC-1[J]  Chinese Pharmaceutical Journal, 2013,V48(1): 17-21
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