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ժҪ Ŀ�� ŵ��׻��С��ն��ѧ��ŵ��ԭ��ҩ��жԱȡ�� ô��峦��ʵ�飬��ֹ��ȷ��ⶨ�Ӻ�Ũ�ȣ�HPLCͬʱ�ⶨ��ŵ��ؼ��ŵ��Ũ�ȡ�� ŵ��׻��С��ʳ��ԭ��ҩ��50~200 μg·mL^-1�ڵ�K_aֵ��ֲ��䣬��pH 6.0��6.5��7.4��µ��Բ��죬��ŵ��׻��ʮ��ָ��ճ��س��᳦��K_aֵ�ֱ�Ϊ(0.373±0.002 1)h^-1��(0.329±0.000 8)h^-1��(0.362±0.001 4)h^-1��(0.347±0.007 9)h^-1�� ŵ��׻��нϺ��գ��һ��ѧ��̣��ջ��Ϊ��ɢ��

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Abstract�� OBJECTIVE To investigate the absorption kinetics of fenofibrate nanosuspension in rat intestine��METHODS The intestine of rats was cannulated for in situ recirculation��UV spectrophotometry was used to determine the concentrations of phenol red while HPLC was used to determine the concentrations of��fenofibrate and fenofibric acid��RESULTS The fenofibrate nanosuspension exhibited substantial absorption enhancement in entire intestine compared to the crude drug solution��The difference in drug absorption at concentrations from 50 to 200 μg·mL^-1 between fenofibrate nanosuspension and crude drug solution was not significant. Different pH values of K-R buffer had no effect on the intestinal permeability (P_app)and absorption rate constant (K_a)for the two dosage forms. The absorption rate constants (h^-1)of fenofibrate nanosuspension at duodenum��jejunum��ileum and colon were (0.373±0.002 1)��(0.329±0.000 8)��(0.362±0.001 4)�� and (0.347±0.007 9)�� respectively��CONCLUSION Fenofibrate nanosuspension can be well absorbed in the whole intestinal segments��The absorption of��fenofibrate nanosuspension in rat intestine is a first order process with passive diffusion mechanism.

Keywords�� fenofibrate nanosuspension, absorption kinetics, in situ intestine absorption

�ո��: 2011-12-01;

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��С��, ��, ��»�� .��ŵ��׻��峦��ն��ѧ�о�[J] �й�ҩѧ��־, 2012,V47(22): 1844-1848

SUN Xiao-Hu, HUANG Qin-Qin, WANG Yong-Lu etc .Absorption Kinetics of Fenofibrate Nanosuspension in Rat Intestine in Situ[J] Chinese Pharmaceutical Journal, 2012,V47(22): 1844-1848

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