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�й�ҩѧ��־ 2012, Vol. 47 Issue (22) :1813-1815    DOI:
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LU Shun-yu�� QI Ping�� LIANG Ying′e�� CHEN Xiao-ying�� LIU Lin�� LIN Jun

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ժҪ Ŀ�� �۲�3-������-4-��������������NFDE6����-2-ͪ��3-acetyl-4-acetoxy- 2-benzoxazolone��TC-3�������Ȼ�̼����С���Ը����˵ı������ã���̽������Ч���ơ����� ���ø�ǻע���������0.15%���Ȼ�̼�Ʊ�С���Ը�����ģ�ͣ�3-������-4-��������������NFDE6����-2-ͪ���������θ��ҩ����ⲻͬ������3-������-4-��������������NFDE6����-2-ͪ�Ը�����С��Ѫ������ᰱ��ת��ø���춬���ᰱ��ת��ø�����Լ�����֯�Ƚ��г��������绯ø���ԡ�����ȩ�ͻ�ԭ�͹��׸��ĺ�����Ӱ�죬ͬʱ�⾵�¹۲����֯�IJ���仯����� 3-������-4-��������������NFDE6����-2-ͪ�����Խ������Ȼ�̼�¼��Ը�����С��Ѫ��Ѫ������ᰱ��ת��ø���춬���ᰱ��ת��ø�Ļ��ԣ����͸��Ƚ�����ȩ�ĺ�����ͬʱ��߸���֯�г��������绯ø�����׸��ĵĻ��ԣ����ܼ������Ȼ�̼�Ը���֯�IJ������ˡ����� 3-������-4-��������������NFDE6����-2-ͪ�����Ȼ�̼��С���Ը����˾���һ���ı������ã��䱣�����ƿ�����������ɻ�����֬�ʹ����������йء�
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Abstract�� OBJECTIVE To study the protective effect of 3-acetyl- 4-acetoxy-2-benzoxazolone on liver injury induced by carbon tetrachloride (CCl4)in mice. METHODS The serum activities of ALT and AST and the levels of MDA�� SOD and GSH in liver tissue were measured in the model of acute liver injury induced by intraperitoneal injection 0.15% CCl4 and hepatic histological changes were observed by optical microscope. RESULTS Compared with control group�� the serum ALT�� AST and the liver tissue MDA activities were significantly lowered�� the levels of SOD and GSH in liver tissue were increased obviously. Histological results showed that 3-acetyl- 4-acetoxy-2-benzoxazolone could ameliorate histological damages induced by CCl4 in mice. CONCLUSION 3-Acetyl- 4-acetoxy-2-benzoxazolone exhibits protective effects on experimental hepatic injury.
Keywords�� 3-acetyl- 4-acetoxy-2-benzoxazolone,   acute liver injury,   CCl4     
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LU Shun-Yu, QI Ping, LIANG Ying-E etc .Protective Effect of 3-Acetyl-4-acetoxy-2-benzoxazolone against Acute Liver Injury Induced by Carbon Tetrachloride in Mice[J]  Chinese Pharmaceutical Journal, 2012,V47(22): 1813-1815
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