OBJECTIVE To study the protective effect of 3-acetyl- 4-acetoxy-2-benzoxazolone on liver injury induced by carbon tetrachloride (CCl4)in mice. METHODS The serum activities of ALT and AST and the levels of MDA， SOD and GSH in liver tissue were measured in the model of acute liver injury induced by intraperitoneal injection 0.15% CCl4 and hepatic histological changes were observed by optical microscope. RESULTS Compared with control group， the serum ALT， AST and the liver tissue MDA activities were significantly lowered， the levels of SOD and GSH in liver tissue were increased obviously. Histological results showed that 3-acetyl- 4-acetoxy-2-benzoxazolone could ameliorate histological damages induced by CCl4 in mice. CONCLUSION 3-Acetyl- 4-acetoxy-2-benzoxazolone exhibits protective effects on experimental hepatic injury.
LU Shun-yu， QI Ping， LIANG Ying′e， CHEN Xiao-ying， LIU Lin， LIN Jun.
Protective Effect of 3-Acetyl-4-acetoxy-2-benzoxazolone against Acute Liver Injury Induced by Carbon Tetrachloride in Mice[J]. Chinese Pharmaceutical Journal, 2012, 47(22): 1813-1815
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