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ժҪ Ŀ�� ۲�3-��-4-��NFDE6��-2-ͪ��3-acetyl-4-acetoxy- 2-benzoxazolone��TC-3��Ȼ�̼��С��Ը��˵ı��ã��̽��Ч��ơ�� ø�ǻע��0.15%��Ȼ�̼�Ʊ�С��Ը��ģ�ͣ�3-��-4-��NFDE6��-2-ͪ��θ��ҩ��ⲻͬ��3-��-4-��NFDE6��-2-ͪ�Ը��С��Ѫ��ᰱ��ת��ø��춬��ᰱ��ת��ø��Լ��֯�Ƚ��г��绯ø��ԡ��ȩ�ͻ�ԭ�͹��׸��ĺ��Ӱ�죬ͬʱ�⾵�¹۲��֯�Ĳ��仯�� 3-��-4-��NFDE6��-2-ͪ��Խ��Ȼ�̼�¼��Ը��С��Ѫ��Ѫ��ᰱ��ת��ø��춬��ᰱ��ת��ø�Ļ��ԣ��͸��Ƚ��ȩ�ĺ��ͬʱ��߸��֯�г��绯ø��׸��ĵĻ��ԣ��ܼ��Ȼ�̼�Ը��֯�Ĳ��ˡ�� 3-��-4-��NFDE6��-2-ͪ��Ȼ�̼��С��Ը��˾��һ��ı��ã��䱣��ƿ��ɻ��֬�ʹ��йء�

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�ؼ���� 3-��-4-��NFDE6��-2-ͪ ��Ը�� Ȼ�̼

Abstract�� OBJECTIVE To study the protective effect of 3-acetyl- 4-acetoxy-2-benzoxazolone on liver injury induced by carbon tetrachloride (CCl₄)in mice. METHODS The serum activities of ALT and AST and the levels of MDA�� SOD and GSH in liver tissue were measured in the model of acute liver injury induced by intraperitoneal injection 0.15% CCl₄ and hepatic histological changes were observed by optical microscope. RESULTS Compared with control group�� the serum ALT�� AST and the liver tissue MDA activities were significantly lowered�� the levels of SOD and GSH in liver tissue were increased obviously. Histological results showed that 3-acetyl- 4-acetoxy-2-benzoxazolone could ameliorate histological damages induced by CCl₄ in mice. CONCLUSION 3-Acetyl- 4-acetoxy-2-benzoxazolone exhibits protective effects on experimental hepatic injury.

Keywords�� 3-acetyl- 4-acetoxy-2-benzoxazolone, acute liver injury, CCl₄

�ո��: 2011-11-10;

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��߼��: ¬˳��Ů��˶ʿ�о�� о�� ͨѶ��ߣ��־��У��ʿ�� о�� Tel��0771��5358277
E-mail��nnlsy2010@163.com

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¬˳��, ��ƽ, ��ӱ�� .3-��-4-��NFDE6��-2-ͪ��Ȼ�̼��С��Ը��˵ı��[J] �й�ҩѧ��־, 2012,V47(22): 1813-1815

LU Shun-Yu, QI Ping, LIANG Ying-E etc .Protective Effect of 3-Acetyl-4-acetoxy-2-benzoxazolone against Acute Liver Injury Induced by Carbon Tetrachloride in Mice[J] Chinese Pharmaceutical Journal, 2012,V47(22): 1813-1815

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