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�й�ҩѧ��־ 2012, Vol. 47 Issue (22) :1807-1812    DOI:
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FU Yong-jin1�� ZHOU Yan1��PAN Jing-qiang1�� ZHANG Xiao-mu1��Lv Jun-hua2

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ժҪ Ŀ�� ̽�ִ�ܺຶ�����������(streptozocin��STZ)�յ�2�����򲡴����������������ü����ơ����� SD����70ֻ�������Ϊ�������ģ���顣���������⣬�������������֬-��������ι��4�ܣ��ٸ������������أ�40 mg·kg-1��ip����72 h��ⶨ�ո�Ѫ�ǣ���Ѫ��ֵ����16.67 mmol·L-1�Ĵ��������Ϊ4�飺ģ���飬����˫���飨250 mg·kg-1������ܺີͼ����飨80 mg·kg-1���͸߼����飨160 mg·kg-1����������ҩ8�ܡ������������ģ����������θ�����������ˮ��ʵ�����ʱ���ⶨ�����ȵ��أ�Ins����Ѫ�ǣ�FSG����Ѫ֬�������ȵ��صֿ�ָ��(HOMA-IRI)���ⶨ�����������򵰰ס�Ѫ���ص���Ѫ�����������ⶨ��������-Ѫ�ܽ�����(Ang ��)��Pѡ����(P-selectin)����������֯����ȩ(MDA)�����ͳ��������绯ø(SOD)���ԡ��⾵�¹۲����ಡ��ѧ�仯����� ��ģ����Ƚϣ�����˫�Һ͸ߡ��ͼ�����ຸܺ�ҩ8�ܺ󣬾������Խ��ʹ���̬�ո�Ѫ�ǣ�P
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Abstract�� OBJECTIVE To investigate the therapeutic effects and mechanisms of tetramethylpyrazine (TMP)on streptozocin (STZ)-induced-nephropathy in type 2 diabetic rats. METHODS Seventy SD rats were divided into control group (n=14)and model group (n=56)at random. The model rats were fed on high fat and sugar diets for 4 weeks and then injected STZ 40 mg·kg-1. After 72 h�� the fasting blood glucose (FBG)was measured. Rats with high FBG above 16.67 mmol·L-1 were randomly divided into four groups�� model�� metformin (Met�� 250 mg·kg-1��and TMP (80��160 mg·kg-1)groups and continuously treated for 8 weeks�� and both the control and model groups were given equal distilled water by intragastric administration. The levels of insulin (Ins)�� fasting serum glucose (FSG)�� total cholesterol (TC)�� low density lipoprotein cholesterol (LDL-C)�� triglyceride (TG)�� free fatty acids (FFAs)�� angiotensin II (Ang II)and P-selectin�� blood urea nitrogen (BUN)�� creatinine(Cr)�� creatinine clearance rate (Ccr)in serum�� contents of nitric oxide (NO)and activities of nitric oxide synthetase (NOS)in serum and renal tissues�� content of malonaldehyde (MDA)and activity of superoxide dismutase (SOD)in renal tissues�� and the insulin resistance index (HOMA-IRI)were measured at the end of the experiment. Besides�� the urine volume and urinary protein were also determined. The nephridial tissues of the treated rats were observed under optical microscope. RESULTS Compared with model group�� the dynamic FBG and total output of urinary protein were significantly decreased (P
Keywords�� tetramethylpyrazine,   diabetic nephropathy,   insulin resistance,   angiotensin ��,   P-selectin     
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FU Yong-Jin, ZHOU Yan, PAN Jing-Qiang etc .The rapeutic Effects and Mechanisms of Tetramethylpyrazine on Streptozocin-Induced-Nephropathy in Type 2 Diabetic Rats[J]  Chinese Pharmaceutical Journal, 2012,V47(22): 1807-1812
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