Abstract��
OBJECTIVE To synthesize a kind of novel cytotoxin with multi-drug-resistance reverting properties and study their cytotoxicity. METHODS The target compounds were obtained from N-benzyl-4-piperidones and benzaldehyde derivatives on the condition of 20 �棬 7-8 h�� taking dry hydrogen chloride as catalyst��using aldol condensation reaction��inspected by TLC and purified through recrystallization. RESULTS Five N-benzyl-3��5-bis(arylmethylene)-4-piperidone derivatives were synthesized. The yield was over 49%. Their structures were characterized by 1H-NMR��ESI-MS with melting points. The data of cytotoxicity was obtained. CONCLUSION The synthetic route is convenient and efficient�� The compounds had good inhibiting activity for a few kinds of tumor cells.
SUN Ju-Feng,
LI Ke-Ke,
ZHANG Shu-Ping
.Synthesis and Cytotoxicity Study of N-Benzyl- 3��5-Bis(Arylmethylene)-4-Piperidones[J] Chinese Pharmaceutical Journal, 2012,V47(19): 1588-1591
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2012, Vol. 47 
