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�й�ҩѧ��־ 2012, Vol. 47 Issue (14) :1154-1157    DOI:
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SU Na��WU Bin�� LU Jing��XU Ting

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Abstract�� OBJECTIVE To review the efficacy and safety of ambroxol for lung protection in perioperative period. METHODS Random controlled trails (RCTs)�� systematic review (SR)�� and meta-analysis of ambroxol for lung protection in perioperative period were searched in Cochrane�� PubMed�� Embase�� ISI�� CBMdisc�� CNKI�� VIP and Wangfang dababase�� the methodology quality of every RCT was evaluated�� then meta-analysis was performed by software of RevMan5.0.0. RESULTS Twelve RCTs of ambroxol for lung protection in perioperative period were included. According to the meta-analysis results�� the ambroxol group was better than the control group in pulmonary complications [RR 0.55��95%CI (0.40�� 0.74)�� P=0. 000 1]�� The cough and expectoration degree in the ambroxol group was better than the control group [RR 1.25��95%CI (1.09�� 1.44)�� P=0.001]. The ambroxol group was also better than the control group in sputum volume [RR 1.24��95%CI(1.12�� 1.38)�� P
Keywords�� ambroxol,   lung protection,   Meta-analysis     
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SU Na, WU Bin, LU Jing etc .Efficacy and Safety of Ambroxol for Lung Protection in Perioperative Period�� A Systematic Review[J]  Chinese Pharmaceutical Journal, 2012,V47(14): 1154-1157
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