摘要
目的 评价氨溴索对于术后肺保护的疗效和安全性。方法 计算机检索Cochrane图书馆、PubMed数据库、Embase数据库、ISI数据库、中国生物医学文献数据库（CBMdisc）、中国期刊全文数据库（CNKI）、中文科技期刊全文数据库（VIP）、万方数字化期刊全文库，纳入氨溴索对比常规/安慰剂对于术后肺保护的随机对照试验（RCT）、系统评价（SR）和Meta分析文献，对纳入文献的随机对照试验进行方法学质量评价和Meta分析，参考纳入文献的系统评价和Meta分析结论。结果 氨溴索对比常规/安慰剂组对于术后肺保护共纳入12个RCT。两组术后肺部并发症发生率差异有统计学意义[RR 0.55，95%CI(0.40， 0.74)]， P=0.000 1。控制术后痰量有效率差异有统计学意义[RR 1.25，95%CI(1.09， 1.44)]， P=0.001；术后咳痰容易度差异有统计学意义[RR 1.24，95%CI(1.12， 1.38)]， P
Abstract
OBJECTIVE To review the efficacy and safety of ambroxol for lung protection in perioperative period. METHODS Random controlled trails (RCTs)， systematic review (SR)， and meta-analysis of ambroxol for lung protection in perioperative period were searched in Cochrane， PubMed， Embase， ISI， CBMdisc， CNKI， VIP and Wangfang dababase； the methodology quality of every RCT was evaluated， then meta-analysis was performed by software of RevMan5.0.0. RESULTS Twelve RCTs of ambroxol for lung protection in perioperative period were included. According to the meta-analysis results， the ambroxol group was better than the control group in pulmonary complications [RR 0.55，95%CI (0.40， 0.74)， P=0. 000 1]， The cough and expectoration degree in the ambroxol group was better than the control group [RR 1.25，95%CI (1.09， 1.44)， P=0.001]. The ambroxol group was also better than the control group in sputum volume [RR 1.24，95%CI(1.12， 1.38)， P
关键词
氨溴索 /
手术肺保护 /
Meta 分析
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Key words
ambroxol /
lung protection /
Meta-analysis
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苏娜，吴斌，卢静，徐珽.
使用氨溴索对于术后肺保护效果的系统评价[J]. 中国药学杂志, 2012, 47(14): 1154-1157
SU Na，WU Bin， LU Jing，XU Ting.
Efficacy and Safety of Ambroxol for Lung Protection in Perioperative Period： A Systematic Review[J]. Chinese Pharmaceutical Journal, 2012, 47(14): 1154-1157
中图分类号：
R969
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参考文献
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脚注
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基金
科技部“十一五”科技支撑项目（2009BAI76B030202）
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